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tpp-2 Tripeptidyl-peptidase 2 [ Caenorhabditis elegans ]

Gene ID: 174018, updated on 23-Nov-2023

Summary

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Gene symbol
tpp-2
Gene description
Tripeptidyl-peptidase 2
Primary source
WormBase:WBGene00017686
Locus tag
CELE_F21H12.6
See related
AllianceGenome:WB:WBGene00017686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tripeptidyl-peptidase activity. Involved in positive regulation of lipid storage. Predicted to be active in cytosol. Is expressed in intestine and nerve ring. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (6092746..6097597, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Fem-3 mRNA-binding factor 2 Neighboring gene DUF19 domain-containing protein Neighboring gene Retinoblastoma-binding protein homolog 5 Neighboring gene ncRNA Neighboring gene RGS domain-containing protein;Regulator of G-protein signaling rgs-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tripeptidyl peptidase II promotes fat formation in a conserved fashion. McKay RM, et al. EMBO Rep, 2007 Dec. PMID 17932511, Free PMC Article
  2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables tripeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tripeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tripeptidyl-peptidase 2
NP_495221.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6092746..6097597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062820.5 → NP_495221.1  Tripeptidyl-peptidase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495221.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09541
    Conserved Domains (3) summary
    cd04857
    Location:64 → 539
    Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
    pfam00082
    Location:277 → 550
    Peptidase_S8; Subtilase family
    pfam12580
    Location:832 → 1017
    TPPII; Tripeptidyl peptidase II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09541.1

Gene LinkOut

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