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Ttl tubulin tyrosine ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 171572, updated on 11-Apr-2024

Summary

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Official Symbol
Ttlprovided by RGD
Official Full Name
tubulin tyrosine ligaseprovided by RGD
Primary source
RGD:621113
See related
Ensembl:ENSRNOG00000018205 AllianceGenome:RGD:621113
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables tubulin-tyrosine ligase activity. Predicted to be involved in C-terminal protein-tyrosinylation; positive regulation of mitotic cell cycle; and regulation of metaphase plate congression. Predicted to act upstream of or within microtubule cytoskeleton organization and regulation of axon extension. Predicted to be located in spindle microtubule. Orthologous to human TTL (tubulin tyrosine ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 217.2), Brain (RPKM 144.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136752025..136781758)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (116298813..116328538)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121596773..121626581)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, pseudogene 1 Neighboring gene zinc finger CCCH type containing 6 Neighboring gene vinculin/alpha-catenin family member 1 Neighboring gene RNA polymerase I subunit B Neighboring gene uncharacterized LOC134486439 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of rat olfactory bulb tubulin tyrosine ligase cDNA: a dominant negative mutant and an antisense cDNA increase the proliferation rate of cells in culture. Mas CR, et al. Neurochem Res, 2002 Nov. PMID 12512949
  2. Tubulin tyrosine ligase: protein and mRNA expression in developing rat skeletal muscle. Arregui CO, et al. Dev Growth Differ, 1997 Apr. PMID 9108330
  3. A vital role of tubulin-tyrosine-ligase for neuronal organization. Erck C, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15899979, Free PMC Article
  4. Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Barisic M, et al. Science, 2015 May 15. PMID 25908662, Free PMC Article
  5. Characterization of the tubulin-tyrosine ligase. Ersfeld K, et al. J Cell Biol, 1993 Feb. PMID 8093886, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin-tyrosine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-tyrosine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin-tyrosine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin-tyrosine ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of metaphase plate congression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metaphase plate congression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tubulin--tyrosine ligase
NP_612545.2
XP_006235008.1
XP_038960141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138536.2 → NP_612545.2  tubulin--tyrosine ligase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9QXJ0, Q9Z1E5
    UniProtKB/TrEMBL
    A6HQ46, G3V8C8
    Related
    ENSRNOP00000024695.5, ENSRNOT00000024694.7
    Conserved Domains (1) summary
    pfam03133
    Location:81 → 366
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    136752025..136781758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104213.2 → XP_038960141.1  tubulin--tyrosine ligase isoform X2

    UniProtKB/Swiss-Prot
    Q9QXJ0, Q9Z1E5
    Conserved Domains (1) summary
    pfam03133
    Location:81 → 339
    TTL; Tubulin-tyrosine ligase family

  2. XM_006234946.5 → XP_006235008.1  tubulin--tyrosine ligase isoform X1

    UniProtKB/Swiss-Prot
    Q9QXJ0, Q9Z1E5
    Related
    ENSRNOP00000090593.1
    Conserved Domains (1) summary
    pfam03133
    Location:81 → 348
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXJ0.1 GenPept UniProtKB/Swiss-Prot:Q9QXJ0

Gene LinkOut

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