U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cox8a cytochrome c oxidase subunit 8A [ Rattus norvegicus (Norway rat) ]

Gene ID: 171335, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Cox8aprovided by RGD
Official Full Name
cytochrome c oxidase subunit 8Aprovided by RGD
Primary source
RGD:620638
See related
AllianceGenome:RGD:620638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and proton transmembrane transport. Predicted to be integral component of membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1825.4), Brain (RPKM 705.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q43
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213831302..213833623, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204402118..204404439, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222466575..222468896, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene uncharacterized LOC108349688 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene heterogeneous nuclear ribonucleoprotein R, pseudogene 2 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene REST corepressor 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Complexity of nucleus-encoded genes of mammalian cytochrome c oxidase. Cao XN, et al. Ann N Y Acad Sci, 1988. PMID 2854406
  2. Molecular cloning and further characterization of cDNAs for rat nuclear-encoded cytochrome c oxidase subunits VIc and VIII. Suske G, et al. Eur J Biochem, 1987 Oct 1. PMID 2822403
  3. [Malignant breast tumors in the population of the province of Varese from 01/01/76 to 12/31/87]. Crosignani P. Pathologica, 1992 Nov-Dec. PMID 1300526
  4. Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone. Sheehan TE, et al. Am J Physiol Endocrinol Metab, 2004 Jun. PMID 14970006
  5. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. Hüttemann M, et al. Gene, 2003 Jul 17. PMID 12909344

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytochrome-c oxidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex IV TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytochrome c oxidase subunit 8A, mitochondrial
Names
cytochrome c oxidase polypeptide VIII-liver
cytochrome c oxidase subunit 8-2
cytochrome c oxidase subunit VIIIa
NP_599172.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134345.1 → NP_599172.1  cytochrome c oxidase subunit 8A, mitochondrial precursor

    See identical proteins and their annotated locations for NP_599172.1

    Status: VALIDATED

    Source sequence(s)
    CB701133, L48209
    UniProtKB/Swiss-Prot
    A0JMZ9, P80433
    UniProtKB/TrEMBL
    A6HZN8
    Conserved Domains (1) summary
    pfam02285
    Location:27 → 67
    COX8; Cytochrome oxidase c subunit VIII

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213831302..213833623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80433.3 GenPept UniProtKB/Swiss-Prot:P80433

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous