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Zfp369 zinc finger protein 369 [ Mus musculus (house mouse) ]

Gene ID: 170936, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp369provided by MGI
Official Full Name
zinc finger protein 369provided by MGI
Primary source
MGI:MGI:2176229
See related
Ensembl:ENSMUSG00000021514 AllianceGenome:MGI:2176229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRIF2; B930030B22Rik; D230020H11Rik
Summary
Enables neurotrophin p75 receptor binding activity. Acts upstream of or within regulation of cell cycle. Located in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human ZNF274 (zinc finger protein 274). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 3.4), thymus adult (RPKM 3.2) and 28 other tissues See more
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Genomic context

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Location:
13 B3; 13 34.47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (65411975..65452038)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (65277228..65304222)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36445 Neighboring gene STARR-seq mESC enhancer starr_34838 Neighboring gene STARR-seq mESC enhancer starr_34839 Neighboring gene predicted gene 10775 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 53789 Neighboring gene predicted gene 7762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Benzel I, et al. Gene, 2001 Dec 27. PMID 11750124
  2. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Marshall KE, et al. Genome Biol, 2002. PMID 12537567, Free PMC Article
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables neurotrophin p75 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neurotrophin receptor-interacting factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178364.5 → NP_848141.3  neurotrophin receptor-interacting factor 2

    See identical proteins and their annotated locations for NP_848141.3

    Status: VALIDATED

    Source sequence(s)
    AC154552
    Consensus CDS
    CCDS26605.2
    UniProtKB/Swiss-Prot
    Q8BJF0, Q8K1Y8, Q921B4
    UniProtKB/TrEMBL
    F8VQL6
    Related
    ENSMUSP00000119114.2, ENSMUST00000126879.8
    Conserved Domains (8) summary
    smart00349
    Location:35 → 94
    KRAB; krueppel associated box
    COG5048
    Location:727 → 792
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:759 → 779
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:676 → 695
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:785 → 807
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:300 → 339
    KRAB; KRAB box
    pfam02023
    Location:179 → 266
    SCAN; SCAN domain
    pfam13465
    Location:799 → 824
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    65411975..65452038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157881.1 → XP_036013774.1  neurotrophin receptor-interacting factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BJF0, Q8K1Y8, Q921B4
    Conserved Domains (6) summary
    sd00017
    Location:706 → 726
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:623 → 642
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:732 → 754
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:246 → 287
    KRAB; KRAB box
    pfam02023
    Location:126 → 208
    SCAN; SCAN domain
    pfam13465
    Location:746 → 771
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011244491.3 → XP_011242793.1  neurotrophin receptor-interacting factor 2 isoform X2

    Conserved Domains (7) summary
    sd00017
    Location:696 → 716
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:613 → 632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:722 → 744
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:236 → 277
    KRAB; KRAB box
    pfam02023
    Location:116 → 203
    SCAN; SCAN domain
    pfam13465
    Location:736 → 761
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 31
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_030247169.2 → XP_030103029.1  neurotrophin receptor-interacting factor 2 isoform X3

    Conserved Domains (6) summary
    sd00017
    Location:664 → 684
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:581 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:690 → 712
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:204 → 245
    KRAB; KRAB box
    pfam02023
    Location:84 → 171
    SCAN; SCAN domain
    pfam13465
    Location:704 → 729
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006517116.5 → XP_006517179.1  neurotrophin receptor-interacting factor 2 isoform X4

    Conserved Domains (2) summary
    smart00349
    Location:35 → 94
    KRAB; krueppel associated box
    pfam02023
    Location:179 → 266
    SCAN; SCAN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921B4.1 GenPept UniProtKB/Swiss-Prot:Q921B4

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