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MIER3 MIER family member 3 [ Homo sapiens (human) ]

Gene ID: 166968, updated on 5-Mar-2024

Summary

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Official Symbol
MIER3provided by HGNC
Official Full Name
MIER family member 3provided by HGNC
Primary source
HGNC:HGNC:26678
See related
Ensembl:ENSG00000155545 MIM:620100; AllianceGenome:HGNC:26678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 18.3), duodenum (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (56919603..56952209, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (57747855..57780385, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (56215430..56247950, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 1 Neighboring gene uncharacterized LOC124901214 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86223 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:56178189-56179388 Neighboring gene uncharacterized LOC105378980 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:56206084-56206905 Neighboring gene SET domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16028 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86248 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86269 Neighboring gene Sharpr-MPRA regulatory region 15622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22576 Neighboring gene uncharacterized LOC124900981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16029 Neighboring gene Sharpr-MPRA regulatory region 9364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition. Peng M, et al. Sci Rep, 2017 Sep 8. PMID 28887525, Free PMC Article
  2. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail. Huang W, et al. Exp Cell Res, 2021 Sep 1. PMID 34242623
  3. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
  4. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
  5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Bantscheff M, et al. Nat Biotechnol, 2011 Mar. PMID 21258344

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
    Title: MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
  2. our data suggested that MIER3 plays a potential tumor suppressor role in CRC progression and may be a potentially valuable clinical prognostic marker of this disease.
    Title: MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition.
  3. Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity.
    Title: Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
  4. Data suggest that the human 5q11.2 breast cancer risk allele marked by rs889312 is mammary gland autonomous, and MIER3 is a candidate breast cancer susceptibility gene.
    Title: Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35954, DKFZp781G1119, DKFZp781I1119, DKFZp686L09111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mesoderm induction early response protein 3
Names
mesoderm induction early response 1, family member 3
mi-er3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297598.2 → NP_001284527.1  mesoderm induction early response protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001284527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008937, AC016644
    Consensus CDS
    CCDS78011.1
    UniProtKB/Swiss-Prot
    Q7Z3K6
    Related
    ENSP00000370624.3, ENST00000381226.7
    Conserved Domains (3) summary
    smart00717
    Location:285 → 332
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:287 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181 → 229
    ELM2; ELM2 domain

  2. NM_001297599.2 → NP_001284528.1  mesoderm induction early response protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001284528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC008937, AC016644
    Consensus CDS
    CCDS75248.1
    UniProtKB/Swiss-Prot
    B4DRI9, B8ZZQ0, Q5CZI0, Q68CS3, Q6MZS7, Q7Z3K6, Q86YG8, Q8NA13
    Related
    ENSP00000370596.3, ENST00000381199.8
    Conserved Domains (2) summary
    cd11661
    Location:282 → 326
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:176 → 224
    ELM2; ELM2 domain

  3. NM_152622.5 → NP_689835.3  mesoderm induction early response protein 3 isoform 3

    See identical proteins and their annotated locations for NP_689835.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has two alternate splice sites in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment and an internal aa, compared to isoform 1.
    Source sequence(s)
    AC008937, AC016644
    Consensus CDS
    CCDS3973.2
    UniProtKB/Swiss-Prot
    Q7Z3K6
    Related
    ENSP00000370611.3, ENST00000381213.7
    Conserved Domains (2) summary
    cd11661
    Location:281 → 325
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:176 → 224
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    56919603..56952209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416840.1 → XP_047272796.1  mesoderm induction early response protein 3 isoform X3

  2. XM_011543217.3 → XP_011541519.1  mesoderm induction early response protein 3 isoform X2

    Conserved Domains (3) summary
    smart00717
    Location:295 → 342
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:297 → 341
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:192 → 240
    ELM2; ELM2 domain

  3. XM_011543216.3 → XP_011541518.1  mesoderm induction early response protein 3 isoform X1

    Conserved Domains (2) summary
    cd11661
    Location:298 → 342
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:192 → 240
    ELM2; ELM2 domain

  4. XM_047416839.1 → XP_047272795.1  mesoderm induction early response protein 3 isoform X3

    Related
    ENSP00000386584.1, ENST00000409421.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    57747855..57780385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351878.1 → XP_054207853.1  mesoderm induction early response protein 3 isoform X2

  2. XM_054351877.1 → XP_054207852.1  mesoderm induction early response protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z3K6.2 GenPept UniProtKB/Swiss-Prot:Q7Z3K6

Gene LinkOut

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