Hdgfl1 HDGF like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdgfl1provided by MGI
Official Full Name: HDGF like 1provided by MGI
Primary source: MGI:MGI:1194493
See related: Ensembl:ENSMUSG00000045835 AllianceGenome:MGI:1194493
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HRP-1; Pwwp1; Hdgfrp1; 4921520N01Rik
Summary: Predicted to enable double-stranded DNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and ganglia. Orthologous to human HDGFL1 (HDGF like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 13; 13 A3.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (26952155..26954148, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (26768172..26770165, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hepatoma-derived growth factor-like protein 1

Names: PWWP domain containing 1; hepatoma derived growth factor-like 1; hepatoma-derived growth factor, related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008232.3 → NP_032258.2 hepatoma-derived growth factor-like protein 1

See identical proteins and their annotated locations for NP_032258.2

Status: VALIDATED

Source sequence(s)

AL662807

Consensus CDS

CCDS26388.1

UniProtKB/TrEMBL

O35539, Q2VPR5

Related

ENSMUSP00000057557.4, ENSMUST00000055915.6

Conserved Domains (1) summary

cd05834
Location:8 → 85

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...