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N ORF9a protein;nucleocapsid protein [ SARS coronavirus Tor2 ]

Gene ID: 1489678, updated on 3-Apr-2024

Summary

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Gene symbol
N
Gene description
ORF9a protein;nucleocapsid protein
Locus tag
sars9a
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

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Sequence:
NC_004718.3 (28120..29388)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF7a protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein Neighboring gene ORF9b protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004718.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging. Chang CK, et al. PLoS One, 2013. PMID 23717688, Free PMC Article
  2. SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism. Lu X, et al. Virus Genes, 2011 Feb. PMID 20976535, Free PMC Article
  3. The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication. Tylor S, et al. Can J Microbiol, 2009 Mar. PMID 19370068
  4. Thermostability of the N-terminal RNA-binding domain of the SARS-CoV nucleocapsid protein: experiments and numerical simulations. Fang HJ, et al. Biophys J, 2009 Mar 4. PMID 19254548, Free PMC Article
  5. Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid protein packaging. Chang CK, et al. J Virol, 2009 Mar. PMID 19052082, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using in vitro pull-down experiments and density glycerol gradients, the authors found that at least 3 regions distributed over its entire length mediate the self-interaction of mouse hepatitis virus (MHV) and severe acute respiratory syndrome coronavirus (SARS-CoV) N protein.
    Title: Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers.
  2. The severe acute respiratory syndrome coronavirus N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase, thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I) and inhibiting TRIM25-mediated RIG-I ubiquitination and activation.
    Title: The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.
  3. Electrostatic repulsion acts as a switch to regulate SARS virus N protein oligomerization.
    Title: Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.
  4. These results suggest that SARS coronavirus could reduce pyruvate kinase activity via its nucleocapsid protein, and this may in turn cause disease.
    Title: SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity.
  5. The co-localization of SARS-CoVN and CXCL16 in the cytoplasm of HEK293FT cells was also shown using confocal laser scanning microscopy.
    Title: Cxcl16 interact with SARS-CoV N protein in and out cell.
  6. The HLA-A 2402 complexed with SARSV N1 showed a novel host strategy to present an immunodominant CTL epitope by intrachain hydrogen bond as a featured epitope.
    Title: Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.
  7. SARS-CoV N interacts with MAP19 and increased the expression of MAP19 in cells.
    Title: [Study on interaction between SARS-CoV N and MAP19].
  8. SARS-CoV N protein specifically modulates transcription of the FGL2 gene to cause fibrosis and vascular thrombosis.
    Title: Severe acute respiratory syndrome coronavirus nucleocapsid protein does not modulate transcription of the human FGL2 gene.
  9. SR-rich motif is critical for effective virus replication.
    Title: The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication.
  10. thermostability of the N-terminal RNA-binding domain (RBD) of the N protein; results showed the thermal-induced unfolding-folding transition of the RBD follows a two-state model with a reversibility >90%
    Title: Thermostability of the N-terminal RNA-binding domain of the SARS-CoV nucleocapsid protein: experiments and numerical simulations.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF9a protein;nucleocapsid protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    28120..29388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009825061.1 nucleocapsid protein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P59595, Q7T3Z4, Q7TA14, Q7TF99, Q80E50
    UniProtKB/TrEMBL
    A0A2D1PX79, A0A2D1PXA5, A0A2D1PXH1, A0A3G5BJ14, A2TGS3, B8Q8R0, B8Q8S2, B8Q8T3, B8Q8U4, B8Q8V5, B8Q8W6, C4P6R7, D2E1E2, D2E1F7, D2E230, D2E275, D2E2E7, D2E2N5, D3KDN4, Q19QW0, Q1EFM2, Q1EFN5, Q3S2B5, Q3ZTD1, Q5DIB8, Q5Y179, Q6GYQ2, Q6JH33, Q6JH41, Q6QJ37, Q6R7X9, Q6RCV8, Q6RCW9, Q6RCY0, Q6RCZ1, Q6RD02, Q6RD13, Q6RD24, Q6RD35, Q6RD46, Q6RD57, Q6S8C7, Q6S8E1, Q6TPE0, Q6UUW1, Q6UZE8, Q6UZF2, Q6V583, Q6VA71, Q6VA82, Q6VA93, U5WIP0, U5WLN3
    Conserved Domains (1) summary
    pfam00937
    Location:41 → 392
    Corona_nucleoca; Coronavirus nucleocapsid protein

  2. YP_009825063.1 ORF9a protein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q7TLC7
    UniProtKB/TrEMBL
    A0A1W6S794, C4P6R9, D2E1E4, D2E1F9, D2E218, D2E232, D2E277, D3KDN6, J9TE29, Q3S2B3, Q3ZTB5, Q3ZTC9, Q3ZTE2, Q4JDQ6, Q6S8C5, Q6S8D9, Q7TEP3
    Conserved Domains (1) summary
    cl38891
    Location:1 → 70
    SARS-CoV_ORF9c; accessory protein ORF9c (also referred to as ORF14) from Severe acute respiratory syndrome-associated coronavirus and related coronaviruses
Nucleotide Protein
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