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ORF7a ORF7a protein [ SARS coronavirus Tor2 ]

Gene ID: 1489674, updated on 18-Aug-2023

Summary

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Gene symbol
ORF7a
Gene description
ORF7a protein
Locus tag
sars7a
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

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Sequence:
NC_004718.3 (27273..27641)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF3b protein Neighboring gene small envelope protein Neighboring gene membrane glycoprotein M Neighboring gene ORF6 protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein Neighboring gene ORF9b protein Neighboring gene ORF9a protein;nucleocapsid protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004718.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor. Karjee S, et al. J Virol, 2010 Oct. PMID 20631126, Free PMC Article
  2. SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. Vasilenko N, et al. Virol J, 2010 Feb 9. PMID 20144233, Free PMC Article
  3. SARS-CoV accessory protein 7a directly interacts with human LFA-1. Hänel K, et al. Biol Chem, 2007 Dec. PMID 18020948
  4. Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappaB activation. Kanzawa N, et al. FEBS Lett, 2006 Dec 22. PMID 17141229, Free PMC Article
  5. Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b. Pekosz A, et al. Adv Exp Med Biol, 2006. PMID 17037516, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 7a accessory protein suppressed both transgene and virus-induced gene silencing by reducing the levels of small interfering RNA
    Title: The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.
  2. In this study the authors present data demonstrating that the SARS-CoV 7a protein interacts with human Ap4A-hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17).
    Title: SARS coronavirus protein 7a interacts with human Ap4A-hydrolase.
  3. overexpression of 7a induces apoptosis via a caspase-dependent pathway in cell lines derived from different organs, including lung, kidney, and liver.
    Title: Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.
  4. analysis of SARS-CoV accessory proteins 7a and 7b
    Title: Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b.
  5. suggest potential involvement of 3a/X1 and 7a/X4 proteins in the pathological inflammatory responses in severe acute respiratory syndrome
    Title: Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappaB activation.
  6. Protein 7a expression was associated with blockage of cell cycle progression at G0/G1 phase in HEK 293 cells, COS-7, and Vero cells via cyclin D3 and rb protein pathways.
    Title: SARS coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin D3/pRb pathway.
  7. severe acute respiratory syndrome coronavirus 7a protein induction of apoptosis is dependent on its interaction with the Bcl-XL protein
    Title: Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF7a protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    27273..27641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009825057.1 ORF7a protein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P59635, Q7TA11, Q7TA17
    UniProtKB/TrEMBL
    A7J8M0, C4P6R3, D2E1D8, D2E1F3, D2E227, D2E271, D2E2I7, D3KDN1, J9T0F7, J9T5H6, J9TEN5, Q19QW4, Q1EFM6, Q1EFN9, Q3S2B9, Q3ZTB9, Q3ZTD4, Q3ZTE7, Q4JDP8, Q4JDR1, Q5Y181, Q692D8, Q6GYQ5, Q6R7Y0, Q6RCV9, Q6RCX0, Q6RCY1, Q6RCZ2, Q6RD03, Q6RD14, Q6RD25, Q6RD36, Q6RD47, Q6RD58, Q6S8D1, Q6SRQ5, Q6SRR0, Q6SRR5, Q6SRS0, Q6SRS5, Q6SRT0, Q6SRT5, Q6SRU0, Q6SRU5, Q6SRV0, Q6SRV5, Q6SRW0, Q6SRW5, Q6SRX0, Q6SRX5, Q6SRY0, Q6SRY5, Q6SRZ0, Q6SZ88, Q6T1D6, Q6VA72, Q6VA83, Q6VA94, Q76XZ9
    Conserved Domains (2) summary
    cd21663
    Location:16 → 24
    ORF7a_SARS-CoV-like; Ig strand A [structural motif]
    pfam08779
    Location:16 → 122
    SARS_X4; SARS coronavirus X4 like
Nucleotide Protein
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