Mtpn myotrophin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtpnprovided by MGI
Official Full Name: myotrophinprovided by MGI
Primary source: MGI:MGI:99445
See related: Ensembl:ENSMUSG00000029840 AllianceGenome:MGI:99445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V1; Gcdp; 5033418D15Rik
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of cardiac muscle hypertrophy; regulation of barbed-end actin filament capping; and regulation of macromolecule biosynthetic process. Predicted to be located in axon and cytosol. Predicted to be part of F-actin capping protein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study congestive heart failure and hypertrophic cardiomyopathy. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 40.2), cortex adult (RPKM 36.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 15.27 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (35485759..35516823, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (35508824..35539888, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data argue that a large pool of freely diffusing, inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex exchange, the formation of weak-capping complexes (CP:CARMIL) at the plasma membrane of protruding edges.
Title: Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges.
miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by repressing myotrophin (V1) protein expression.
Title: miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression.
actin-capping protein binds to the filament barbed end of myotrophin/V-1
Title: Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end.
Rat neonatal cardiac myocytes incubated with myotrophin showed an increase in c-myc, c-fos, and c-jun RNA levels and an increase in connexin 43, atrial natriuretic factor, skeletal alpha-actin, and total myosin transcript levels.
Title: Myotrophin induces early response genes and enhances cardiac gene expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128214 (e-PCR)
- UniSTS:211522

RH134386 (e-PCR)
- UniSTS:217668

RH142244 (e-PCR)
- UniSTS:231492

WI-21170 (e-PCR)
- UniSTS:13149

RH135242 (e-PCR)
- UniSTS:218519

Mtpn (e-PCR), detects polymorphism
- UniSTS:507074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macromolecule biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myotrophin

Names: granule cell differentiation protein; protein V-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.