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Col19a1 collagen, type XIX, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 12823, updated on 26-Mar-2024

Summary

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Official Symbol
Col19a1provided by MGI
Official Full Name
collagen, type XIX, alpha 1provided by MGI
Primary source
MGI:MGI:1095415
See related
Ensembl:ENSMUSG00000026141 AllianceGenome:MGI:1095415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within extracellular matrix organization and skeletal muscle tissue development. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including bone; brain; genital tubercle; musculature; and sensory organ. Orthologous to human COL19A1 (collagen type XIX alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.9), frontal lobe adult (RPKM 2.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Col19a1 in Genome Data Viewer
Location:
1 A5; 1 9.99 cM
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (24296764..24627870, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (24257683..24587922, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 135, member A Neighboring gene STARR-seq mESC enhancer starr_00445 Neighboring gene predicted gene, 30756 Neighboring gene collagen, type IX, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_00447 Neighboring gene STARR-seq mESC enhancer starr_00448 Neighboring gene STARR-seq mESC enhancer starr_00450 Neighboring gene STARR-seq mESC enhancer starr_00451 Neighboring gene predicted gene, 26418 Neighboring gene tubulin, beta 4B class IVB, pseudogene 2 Neighboring gene predicted gene 10222

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX. Sato H, et al. Histochem Cell Biol, 2022 Feb. PMID 34993640
  2. Loss of Interneuron-Derived Collagen XIX Leads to a Reduction in Perineuronal Nets in the Mammalian Telencephalon. Su J, et al. ASN Neuro, 2017 Feb. PMID 28090790, Free PMC Article
  3. Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses. Su J, et al. J Comp Neurol, 2010 Jan 10. PMID 19937713, Free PMC Article
  4. Trimerization and triple helix stabilization of the collagen XIX NC2 domain. Boudko SP, et al. J Biol Chem, 2008 Dec 5. PMID 18845531, Free PMC Article
  5. Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family. Khaleduzzaman M, et al. Genomics, 1997 Oct 15. PMID 9344653

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX.
    Title: Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX.
  2. Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
    Title: Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
  3. The results of this study suggested a mechanism by which the loss of collagen XIX speeds Perineuronal Nets degradation in Telencephalon degradation.
    Title: Loss of Interneuron-Derived Collagen XIX Leads to a Reduction in Perineuronal Nets in the Mammalian Telencephalon.
  4. these data not only reveal that collagen XIX is expressed by central neurons, but show for the first time that a nonfibrillar collagen is necessary for the formation of hippocampal synapses
    Title: Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses.
  5. The NC2 domain of collagen XIX and probably of other FACITs is responsible for chain selection and trimerization
    Title: Trimerization and triple helix stabilization of the collagen XIX NC2 domain.
  6. Collagen XIX has a role in esophageal muscle development and function
    Title: Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring tensile strength IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
collagen alpha-1(XIX) chain
Names
collagen alpha-1(Y) chain
procollagen, type XIX, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007733.2 → NP_031759.2  collagen alpha-1(XIX) chain precursor

    See identical proteins and their annotated locations for NP_031759.2

    Status: VALIDATED

    Source sequence(s)
    AC130201, AC153653, AK019854, AK149136, BC118970, BY247446
    Consensus CDS
    CCDS14854.1
    UniProtKB/Swiss-Prot
    O35053, Q0VF58
    UniProtKB/TrEMBL
    F8WHV4
    Related
    ENSMUSP00000110899.3, ENSMUST00000115244.9
    Conserved Domains (2) summary
    pfam01391
    Location:519 → 576
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:50 → 229
    TSPN; Thrombospondin N-terminal -like domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    24296764..24627870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495645.5 → XP_006495708.1  collagen alpha-1(XIX) chain isoform X4

    See identical proteins and their annotated locations for XP_006495708.1

    UniProtKB/Swiss-Prot
    O35053, Q0VF58
    UniProtKB/TrEMBL
    F8WHV4
    Conserved Domains (2) summary
    pfam01391
    Location:519 → 576
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:50 → 229
    TSPN; Thrombospondin N-terminal -like domains

  2. XM_030245411.2 → XP_030101271.1  collagen alpha-1(XIX) chain isoform X6

    UniProtKB/TrEMBL
    F8WHV4
    Conserved Domains (2) summary
    pfam01391
    Location:515 → 572
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:76 → 255
    TSPN; Thrombospondin N-terminal -like domains

  3. XM_006495646.5 → XP_006495709.1  collagen alpha-1(XIX) chain isoform X5

    UniProtKB/TrEMBL
    F8WHV4
    Conserved Domains (2) summary
    pfam01391
    Location:515 → 572
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:76 → 255
    TSPN; Thrombospondin N-terminal -like domains

  4. XM_006495644.5 → XP_006495707.1  collagen alpha-1(XIX) chain isoform X3

    UniProtKB/TrEMBL
    F8WHV4
    Conserved Domains (2) summary
    pfam01391
    Location:527 → 584
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:76 → 255
    TSPN; Thrombospondin N-terminal -like domains

  5. XM_006495643.5 → XP_006495706.1  collagen alpha-1(XIX) chain isoform X2

    UniProtKB/TrEMBL
    F8WHV4
    Conserved Domains (2) summary
    pfam01391
    Location:545 → 602
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:76 → 255
    TSPN; Thrombospondin N-terminal -like domains

  6. XM_006495642.5 → XP_006495705.1  collagen alpha-1(XIX) chain isoform X1

    UniProtKB/TrEMBL
    F8WHV4
    Conserved Domains (2) summary
    pfam01391
    Location:545 → 602
    Collagen; Collagen triple helix repeat (20 copies)
    smart00210
    Location:76 → 255
    TSPN; Thrombospondin N-terminal -like domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VF58.2 GenPept UniProtKB/Swiss-Prot:Q0VF58

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