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arc Arc-like repressor [ Salmonella phage P22 ]

Gene ID: 1262795, updated on 21-Jun-2023

Summary

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Gene symbol
arc
Gene description
Arc-like repressor
Locus tag
P22gp18
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella phage P22 (nat-host: Salmonella enterica subsp. enterica serovar Typhimurium)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Lederbergvirus
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Genomic context

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Sequence:
NC_002371.2 (14793..15022)

NC_002371.2Genomic Context describing neighboring genes Neighboring gene superinfection exclusion SieA-like Neighboring gene hypothetical protein Neighboring gene partition protein ATPase Neighboring gene Ant Neighboring gene miscRNA Neighboring gene tail spike protein Neighboring gene GtrC-like O-antigen conversion translocase Neighboring gene GtrB glycosyltransferase for O-antigen conversion Neighboring gene GtrA-like O-antigen conversion

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002371.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigation of arc repressor DNA-binding specificity by comparative molecular dynamics simulations. Song W, et al. J Biomol Struct Dyn, 2015. PMID 25495540
  2. Protein quadratic indices of the "macromolecular pseudograph's alpha-carbon atom adjacency matrix". 1. Prediction of Arc repressor alanine-mutant's stability. Ponce YM, et al. Molecules, 2004 Dec 31. PMID 18007508, Free PMC Article
  3. Sequence determinants of a conformational switch in a protein structure. Anderson TA, et al. Proc Natl Acad Sci U S A, 2005 Dec 20. PMID 16344489, Free PMC Article
  4. Arc repressor-operator DNA interactions and contribution of Phe10 to binding specificity. Dostál L, et al. Biochemistry, 2005 Jun 14. PMID 15938628
  5. Origins of DNA-binding specificity: role of protein contacts with the DNA backbone. Schildbach JF, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927650, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The arc repressor DNA-binding specificity has been presented using comparative molecular dynamics simulations.
    Title: Investigation of arc repressor DNA-binding specificity by comparative molecular dynamics simulations.
  2. Preponderance of hydrophobic and electronic features over bulk-steric characteristics of Arc indicates the higher importance of hydrophobic and electronic side chain terms in the folding and stability of the engineered Arc dimer. [REVIEW]
    Title: Protein quadratic indices of the "macromolecular pseudograph's alpha-carbon atom adjacency matrix". 1. Prediction of Arc repressor alanine-mutant's stability.
  3. Structure activity relationship: Arc mutants in which position 11 is occupied by Gly, Ala, Val, Ile, Leu, Met, Phe, or Tyr
    Title: Sequence determinants of a conformational switch in a protein structure.
  4. Apparently, looping out of the phenylalanine side chain at position 10 of the Arc repressor enhances the specific interaction with Arc operator DNA and results in energetically favorable complexes.
    Title: Arc repressor-operator DNA interactions and contribution of Phe10 to binding specificity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

protein_bind

  • Loc: 14798-14818 bound_moiety = Arc repressor
  • Loc: 14822-14844 bound_moiety = Mnt protein

regulatory

  • Loc: 14793-14821 regulatory_class = promoter

General protein information

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Preferred Names
Arc-like repressor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002371.2 Reference assembly

    Range
    14793..15022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_059642.1 Arc-like repressor [Salmonella phage P22]

    See identical proteins and their annotated locations for NP_059642.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03050, Q77D84, Q7PCJ3
    UniProtKB/TrEMBL
    A0A0N7CAL4, A0A0N7CE43, A0A0N7CGL0, A0A7T8EMZ5, A8CG91
    Conserved Domains (1) summary
    pfam03869
    Location:4 → 53
    Arc; Arc-like DNA binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1PAR_A.1
1PAR_B.1
1PAR_C.1
1PAR_D.1

Gene LinkOut

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