Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp1b2provided by MGI
Official Full Name: ATPase, Na+/K+ transporting, beta 2 polypeptideprovided by MGI
Primary source: MGI:MGI:88109
See related: Ensembl:ENSMUSG00000041329 AllianceGenome:MGI:88109
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Amog; Atpb-2
Summary: Predicted to enable several functions, including ATPase binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in cell-substrate adhesion; negative regulation of glial cell migration; and positive regulation of neuron projection development. Acts upstream of or within several processes, including brain development; motor behavior; and photoreceptor cell maintenance. Located in several cellular components, including astrocyte end-foot; cell body membrane; and photoreceptor inner segment. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and retina. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 174.0), cortex adult (RPKM 64.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69490554..69496786, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69599728..69605978, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a functional link between the Na,K-ATPase beta2-subunit and Merlin/NF2 and suggest a role for the beta2-subunit in regulating cytoskeletal dynamics and Hippo/YAP signaling during neuronal differentiation, is reported.
Title: A Functional Interaction Between Na,K-ATPase β(2)-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells.
These and previous results led us to suggest an induced-fit binding mechanism for the interaction between retinoschisin and the Na/K-ATPase, which is dependent on threonine 240 in ATP1B2 allowing the accommodation of hyperflexible retinoschisin spikes by the associated protein-protein interaction patch on ATP1B2.
Title: Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.
Functional selection and assembly of NKA subunit isoforms occurs in the cochlear stria vascularis lateral wall, which is disrupted and dysregulated with age.
Title: Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea.
The results of this study show that the astrocytic Na+/K+-ATPase activity is dominated by the catalytic subunit of the alpha2 subtype.
Title: The α2β2 isoform combination dominates the astrocytic Na(+) /K(+) -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation.
Atp1alpha2 is preferentially expressed with Atp1beta2 in T-tubules of cardiac myocytes, forming alpha2beta2 heterodimers.
Title: Selective Assembly of Na,K-ATPase α2β2 Heterodimers in the Heart: DISTINCT FUNCTIONAL PROPERTIES AND ISOFORM-SELECTIVE INHIBITORS.
ATP1B2 is stably expressed in multiple models of CNS injury and disease.
Title: An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody.
PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.
Title: PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H(+)-ATP Synthase.
Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 and ATP1B2.
Title: The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.
A novel role for a glial adhesion molecule in cell size regulation through selective activation of the Akt/mTOR/S6K signal transduction pathway was shown.
Title: Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.
Beta(2) isoforms increase postnatally and show greater muscle variation.
Title: Na,K-ATPase alpha- and beta-isoform expression in developing skeletal muscles: alpha(2) correlates with t-tubule formation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Atp1b2 (e-PCR), detects polymorphism
- UniSTS:480323

Atp1b2 (e-PCR), detects polymorphism
- UniSTS:141128

Atp1b2 (e-PCR), detects polymorphism
- UniSTS:141129

Atp1b2 (e-PCR), detects polymorphism
- UniSTS:546668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables P-type sodium:potassium-exchanging transporter activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasma membrane bounded cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within third ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in astrocyte end-foot	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron to neuron synapse	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium:potassium-exchanging ATPase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit beta-2

Names: adhesion molecule in glia; glial cell adhesion molecule; sodium/potassium-dependent ATPase subunit beta-2

NP_038201.1

EC 7.2.2.13

XP_017169721.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013415.6 → NP_038201.1 sodium/potassium-transporting ATPase subunit beta-2

See identical proteins and their annotated locations for NP_038201.1

Status: VALIDATED

Source sequence(s)

AK141786, AK158321, CX204070

Consensus CDS

CCDS24898.1

UniProtKB/Swiss-Prot

P14231

UniProtKB/TrEMBL

Q3UR55

Related

ENSMUSP00000047353.7, ENSMUST00000047889.13

Conserved Domains (1) summary

TIGR01107
Location:2 → 289

Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69490554..69496786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314232.3 → XP_017169721.1 sodium/potassium-transporting ATPase subunit beta-2 isoform X1

Conserved Domains (1) summary

cl08255
Location:1 → 236

Na_K-ATPase; Sodium / potassium ATPase beta chain