Agtr1b angiotensin II receptor, type 1b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agtr1bprovided by MGI
Official Full Name: angiotensin II receptor, type 1bprovided by MGI
Primary source: MGI:MGI:87965
See related: Ensembl:ENSMUSG00000054988 AllianceGenome:MGI:87965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AT1B; AT2R1B; Agtr-1b; Angtr-1b
Summary: Predicted to enable angiotensin receptor activity; bradykinin receptor binding activity; and protein heterodimerization activity. Involved in multicellular organism aging and regulation of blood pressure. Acts upstream of or within several processes, including blood vessel development; drinking behavior; and regulation of systemic arterial blood pressure by circulatory renin-angiotensin. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 2.3), bladder adult (RPKM 0.4) and 5 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 A2; 3 6.37 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (20368637..20421341, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (20314473..20367177, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease.
Title: Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease.
AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model.
Title: AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model.
AT1Rb and total AT1R expression levels are much lower in parenchymal arterioles compared with pial arteries and that parenchymal arterioles are less sensitive to the vasoconstrictive effects of the endogenous AT1R ligand angiotensin II (ANG II)
Title: Differential expression of angiotensin II type 1 receptor subtypes within the cerebral microvasculature.
Reduced expression of AT1 receptors in renal stromal progenitors and their descendants does not disturb normal kidney development.
Title: Apparently normal kidney development in mice with conditional disruption of ANG II-AT(1) receptor genes in FoxD1-positive stroma cell precursors.
Results suggest the involvement of angiotensin II (Ang II), through its angiotensin type-1 receptor (AT1R) in the inflammation induced by Aah venom, in the heart and the aorta.
Title: Role of angiotensin II and angiotensin type-1 receptor in scorpion venom-induced cardiac and aortic tissue inflammation.
AT1R up-regulation in the stomach may help compensate for interstitial cells of Cajal loss in diabetic mice.
Title: Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice.
Suggest that myogenic tone is determined by AT1 and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation.
Title: Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report.
Regional abundance of AT1b receptor mRNA coincided with AngII-induced regional contractility, but it was not associated with AngII-induced aortic pathologies.
Title: Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms.
Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity.
Title: Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity.
Demonstrate that angiotensin II signaling through AT1a and AT1b receptor pathways does not seem to be essential for the development of pancreatitis in the mouse model of pancreatitis induced by repetitive cerulein injury.
Title: Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

Go to the top of the page Help

Markers

PMC28071P1 (e-PCR)
- UniSTS:272401

Agtr1a (e-PCR), detects polymorphism
- UniSTS:516680

UniSTS:256385 (e-PCR)
- UniSTS:256385

Agtr1a (e-PCR), detects polymorphism
- UniSTS:256385

UniSTS:256387 (e-PCR)
- UniSTS:256387

Agtr1b (e-PCR), detects polymorphism
- UniSTS:256387

NoName (e-PCR)
- UniSTS:484823

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables angiotensin type I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin type I receptor activity	ISO Inferred from Sequence Orthology more info
enables angiotensin type II receptor activity	ISO Inferred from Sequence Orthology more info
enables bradykinin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within brain renin-angiotensin system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within drinking behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: type-1 angiotensin II receptor B

Names: AT1 receptor B; AT3; angiotensin II type-1 receptor B; angiotensin II type-1B receptor; type-1B angiotensin II receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175086.3 → NP_780295.2 type-1 angiotensin II receptor B

See identical proteins and their annotated locations for NP_780295.2

Status: VALIDATED

Source sequence(s)

AK087228, BC109153

Consensus CDS

CCDS17264.1

UniProtKB/Swiss-Prot

P29755

UniProtKB/TrEMBL

Q32MF7, Q8BU69

Related

ENSMUSP00000068298.8, ENSMUST00000068316.8

Conserved Domains (2) summary

pfam00001
Location:45 → 302

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 262

7tm_4; Olfactory receptor