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Mpi mannose phosphate isomerase [ Mus musculus (house mouse) ]

Gene ID: 110119, updated on 17-Mar-2024

Summary

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Official Symbol
Mpiprovided by MGI
Official Full Name
mannose phosphate isomeraseprovided by MGI
Primary source
MGI:MGI:97075
See related
Ensembl:ENSMUSG00000032306 AllianceGenome:MGI:97075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpi1; Mpi-1; 1110002E17Rik
Summary
Enables mannose-6-phosphate isomerase activity. Acts upstream of or within GDP-mannose biosynthetic process and mannose to fructose-6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 49.7), large intestine adult (RPKM 32.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Mpi in Genome Data Viewer
Location:
9 B; 9 31.05 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57448744..57460095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57544260..57552812, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24239 Neighboring gene ribonuclease P/MRP 25 subunit Neighboring gene STARR-positive B cell enhancer ABC_E11408 Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene family with sequence similarity 219, member B Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51-like kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells. Fujita N, et al. FEBS J, 2008 Feb. PMID 18215164
  2. Metabolically programmed quality control system for dolichol-linked oligosaccharides. Harada Y, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218558, Free PMC Article
  3. Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. DeRossi C, et al. J Biol Chem, 2006 Mar 3. PMID 16339137
  4. Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase. Davis JA, et al. Glycobiology, 2002 Jul. PMID 12122025
  5. [Presence of a male sterility factor, Hst-2, segregating in interspecies crosses. M. musculus L. x M. spretus Lastaste and linked to Mod-1, and Mpi-1 on chromosome 9]. Bonhomme F, et al. C R Seances Acad Sci III, 1982 Apr 19. PMID 6812867

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.
    Title: PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.
  2. Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
    Title: Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.
  3. Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
    Title: Ontogeny of D-mannose transport and metabolism in rat small intestine.
  4. Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
    Title: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.
  5. Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
    Title: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-6-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannose-6-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose-6-phosphate isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GDP-mannose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process from mannose through fructose-6-phosphate IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within mannose to fructose-6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose to fructose-6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mannose-6-phosphate isomerase
Names
PMI
mannose phosphate isomerase 1
phosphohexomutase
phosphomannose isomerase
NP_080113.1
XP_006510834.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025837.2 → NP_080113.1  mannose-6-phosphate isomerase

    See identical proteins and their annotated locations for NP_080113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK132777
    Consensus CDS
    CCDS40650.1
    UniProtKB/Swiss-Prot
    Q924M7
    UniProtKB/TrEMBL
    Q3V100, Q921Z9
    Related
    ENSMUSP00000034856.9, ENSMUST00000034856.15
    Conserved Domains (2) summary
    COG1482
    Location:9 → 403
    ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
    pfam01238
    Location:6 → 381
    PMI_typeI; Phosphomannose isomerase type I

RNA

  1. NR_151692.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC164548

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57448744..57460095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510771.4 → XP_006510834.1  mannose-6-phosphate isomerase isoform X1

    Conserved Domains (1) summary
    cl21464
    Location:3 → 192
    cupin_like; Conserved domain found in cupin and related proteins

RNA

  1. XR_001778789.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924M7.1 GenPept UniProtKB/Swiss-Prot:Q924M7

Gene LinkOut

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