U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnh1 ribonuclease/angiogenin inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 107702, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Rnh1provided by MGI
Official Full Name
ribonuclease/angiogenin inhibitor 1provided by MGI
Primary source
MGI:MGI:1195456
See related
Ensembl:ENSMUSG00000038650 AllianceGenome:MGI:1195456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNH
Summary
Predicted to enable ribonuclease inhibitor activity. Predicted to be involved in regulation of angiogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of angiogenin-PRI complex. Is expressed in bladder and pancreas. Orthologous to human RNH1 (ribonuclease/angiogenin inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 94.0), adrenal adult (RPKM 89.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rnh1 in Genome Data Viewer
Location:
7 F5; 7 86.44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140740239..140752764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141160326..141172851, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560 Neighboring gene phosphatidylserine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E8222 Neighboring gene STARR-positive B cell enhancer ABC_E9715 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2. Wu T, et al. Microb Pathog, 2010 Jul-Aug. PMID 20307645
  2. Evolution of ribonuclease inhibitor by exon duplication. Haigis MC, et al. Mol Biol Evol, 2002 Jun. PMID 12032252
  3. LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Bombaci G, et al. Life Sci Alliance, 2022 Jun. PMID 35256513, Free PMC Article
  4. Expression of mRNAs of pancreatic and L type RNase inhibitors as a function of age in different tissues of SAMP8 and BDF1 mice. Semsei I, et al. Mech Ageing Dev, 1997 Sep. PMID 9234238
  5. Functional evolution of ribonuclease inhibitor: insights from birds and reptiles. Lomax JE, et al. J Mol Biol, 2014 Aug 26. PMID 24941155, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNH1 binds to the 40S subunit of ribosomes and facilitates polysome formation on Gata1 mRNA to confer transcript-specific translation.
    Title: Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
  2. X-ray crystallographic analysis of RNH1 from mouse, bovine and chicken binding to RNase reveals two residues that appear to contribute to the differential binding affinity.
    Title: Functional evolution of ribonuclease inhibitor: insights from birds and reptiles.
  3. Mouse angiogenin inhibitor 1 interacts with hylA of Streptococcus suis.
    Title: Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribonuclease inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of angiogenin-PRI complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of angiogenin-PRI complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribonuclease inhibitor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172100.1 → NP_001165571.1  ribonuclease inhibitor isoform a

    See identical proteins and their annotated locations for NP_001165571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a), which is shorter than isoform b.
    Source sequence(s)
    AK141351, BY114445, BY574079
    Consensus CDS
    CCDS22002.1
    UniProtKB/Swiss-Prot
    Q91VI7, Q924P4
    UniProtKB/TrEMBL
    Q3UM23
    Related
    ENSMUSP00000133061.2, ENSMUST00000167493.9
    Conserved Domains (3) summary
    smart00368
    Location:335 → 362
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:1 → 320
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2 → 24
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_001172101.1 → NP_001165572.1  ribonuclease inhibitor isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' splice pattern and uses a distinct start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AK141351, BY085526, BY574079
    Consensus CDS
    CCDS85455.1
    UniProtKB/TrEMBL
    A0A1B0GSG5, Q3UM23
    Related
    ENSMUSP00000147928.2, ENSMUST00000210314.2
    Conserved Domains (4) summary
    smart00368
    Location:371 → 398
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    COG4886
    Location:46 → 361
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:37 → 356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_145135.3 → NP_660117.2  ribonuclease inhibitor isoform a

    See identical proteins and their annotated locations for NP_660117.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a), which is shorter than isoform b.
    Source sequence(s)
    AK141351, BM946973, BY574079
    Consensus CDS
    CCDS22002.1
    UniProtKB/Swiss-Prot
    Q91VI7, Q924P4
    UniProtKB/TrEMBL
    Q3UM23
    Related
    ENSMUSP00000101651.4, ENSMUST00000106033.5
    Conserved Domains (3) summary
    smart00368
    Location:335 → 362
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:1 → 320
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2 → 24
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140740239..140752764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VI7.1 GenPept UniProtKB/Swiss-Prot:Q91VI7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous