Gene description

dihydroorotate dehydrogenase 2

Locus Tag

blr1140

Gene type

protein coding

RefSeq status

Reviewed

Organism

Bradyrhizobium japonicum USDA 110

Lineage

Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium

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Names

dihydroorotate dehydrogenase 2

NP_767780.1

EC 1.3.3.1

catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

mRNA and Protein(s)

1. NP_767780.1 dihydroorotate dehydrogenase 2 [Bradyrhizobium japonicum USDA 110]

   UniProtKB/Swiss-Prot

   Q89VA7

   Conserved Domains (2) summary

   COG0167
   Location:44 – 353
   Blast Score: 681

   PyrD; Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]

   cd04738
   Location:11 – 334
   Blast Score: 1069

   DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...