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NCOA1 nuclear receptor coactivator 1 [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100995476, updated on 8-Mar-2024

Summary

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Gene symbol
NCOA1
Gene description
nuclear receptor coactivator 1
See related
Ensembl:ENSPPAG00000042202
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 12 NC_073261.2 (101755028..102031268, complement)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 2A NC_073250.1 (101759056..102035245, complement)

Chromosome 12 - NC_073261.2Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 3 Neighboring gene centromere protein O Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene collagen alpha-2(I) chain-like Neighboring gene large ribosomal subunit protein eL42-like Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene intersectin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073261.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    101755028..102031268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034952725.3 → XP_034808616.1  nuclear receptor coactivator 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R9CAU3
    Conserved Domains (9) summary
    PHA03247
    Location:974 → 1309
    PHA03247; large tegument protein UL36; Provisional
    cd00130
    Location:120 → 213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd18948
    Location:27 → 87
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins
    pfam07469
    Location:1212 → 1268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924 → 969
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632 → 708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260 → 370
    PAS_11; PAS domain
    pfam16279
    Location:741 → 818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468 → 590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  2. XM_055108162.2 → XP_054964137.1  nuclear receptor coactivator 1 isoform X2

  3. XM_034952724.3 → XP_034808615.1  nuclear receptor coactivator 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R9CAU3
    Conserved Domains (9) summary
    PHA03247
    Location:974 → 1309
    PHA03247; large tegument protein UL36; Provisional
    cd00130
    Location:120 → 213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd18948
    Location:27 → 87
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins
    pfam07469
    Location:1212 → 1268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924 → 969
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632 → 708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260 → 370
    PAS_11; PAS domain
    pfam16279
    Location:741 → 818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468 → 590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  4. XM_055108164.1 → XP_054964139.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R9CDJ4

  5. XM_055108163.2 → XP_054964138.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R9CDJ4
Nucleotide Protein
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