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MLH1 mutL homolog 1 [ Sus scrofa (pig) ]

Gene ID: 100337665, updated on 8-Mar-2024

Summary

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Official Symbol
MLH1provided by VGNC
Official Full Name
mutL homolog 1provided by VGNC
Primary source
VGNC:VGNC:90252
See related
Ensembl:ENSSSCG00000024222
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in ovary (RPKM 22.1), spleen (RPKM 5.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See MLH1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (21791276..21877789, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (23613450..23692364)

Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain Neighboring gene uncharacterized LOC110256567 Neighboring gene uncharacterized LOC100737115 Neighboring gene LRR binding FLII interacting protein 2 Neighboring gene transgelin-2 pseudogene Neighboring gene uncharacterized LOC106508187 Neighboring gene EPM2A interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Assignment of three novel genes to porcine chromosome 13 by a radiation hybrid panel. Wang H, et al. Cytogenet Genome Res, 2005. PMID 15628038
  2. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MutLalpha complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein Mlh1
Names
mutL homolog 1, colon cancer, nonpolyposis type 2
mutL-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172367.1 → NP_001165838.1  DNA mismatch repair protein Mlh1

    See identical proteins and their annotated locations for NP_001165838.1

    Status: PROVISIONAL

    Source sequence(s)
    GU373696
    UniProtKB/TrEMBL
    A0A8D0UUS1, A0A8D1MK91, D3K5L8, I3LT92
    Related
    ENSSSCP00000027336.2, ENSSSCT00000027443.4
    Conserved Domains (4) summary
    cd03483
    Location:211 → 335
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    TIGR00585
    Location:6 → 315
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:502 → 757
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl00075
    Location:31 → 127
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

    Range
    21791276..21877789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021068364.1 → XP_020924023.1  DNA mismatch repair protein Mlh1 isoform X1

    UniProtKB/TrEMBL
    A0A8D1E1G3
    Conserved Domains (3) summary
    cd03483
    Location:1 → 94
    MutL_Trans_MLH1; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in ...
    pfam16413
    Location:262 → 516
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19 → 216
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]

  2. XM_021068365.1 → XP_020924024.1  DNA mismatch repair protein Mlh1 isoform X1

    UniProtKB/TrEMBL
    A0A8D1E1G3
    Conserved Domains (3) summary
    cd03483
    Location:1 → 94
    MutL_Trans_MLH1; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in ...
    pfam16413
    Location:262 → 516
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19 → 216
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]

  3. XM_021068366.1 → XP_020924025.1  DNA mismatch repair protein Mlh1 isoform X1

    UniProtKB/TrEMBL
    A0A8D1E1G3
    Conserved Domains (3) summary
    cd03483
    Location:1 → 94
    MutL_Trans_MLH1; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in ...
    pfam16413
    Location:262 → 516
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19 → 216
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version

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