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dlk2 delta-like 2 homolog (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 100150992, updated on 27-Mar-2024

Summary

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Official Symbol
dlk2provided by ZNC
Official Full Name
delta-like 2 homolog (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-081107-4
See related
Ensembl:ENSDARG00000076247 AllianceGenome:ZFIN:ZDB-GENE-081107-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-117c8.3
Summary
Predicted to enable Notch binding activity. Acts upstream of or within negative regulation of Notch signaling pathway; negative regulation of angiogenesis; and vasculature development. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See dlk2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4169065..4214014)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4040796..4085495)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene tight junction associated protein 1 (peripheral) Neighboring gene uncharacterized LOC110440172 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene male-enhanced antigen 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis. Rodríguez P, et al. Cardiovasc Res, 2012 Feb 1. PMID 22068159
  2. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein delta homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    4169065..4214014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480711.1 → XP_021336386.1  protein delta homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B7S7
    Conserved Domains (1) summary
    cd00054
    Location:216 → 252
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. XM_009307072.3 → XP_009305347.1  protein delta homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_009305347.1

    UniProtKB/TrEMBL
    A0A8M9PYA6
    Conserved Domains (1) summary
    cd00054
    Location:221 → 257
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. XM_009307075.3 → XP_009305350.1  protein delta homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B7S7
    Conserved Domains (1) summary
    cd00054
    Location:216 → 252
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  4. XM_009307076.3 → XP_009305351.1  protein delta homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B4Z9
    Conserved Domains (1) summary
    cd00054
    Location:215 → 251
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  5. XM_001921677.5 → XP_001921712.2  protein delta homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_001921712.2

    UniProtKB/TrEMBL
    A0A8M9PYA6
    Conserved Domains (1) summary
    cd00054
    Location:221 → 257
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  6. XM_021480712.1 → XP_021336387.1  protein delta homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PYA6
    Related
    ENSDARP00000118418.1, ENSDART00000134105.2
    Conserved Domains (1) summary
    cd00054
    Location:221 → 257
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Nucleotide Protein Strain
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