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ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009345, updated on 8-Mar-2024

Summary

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Gene symbol
ITIH2
Gene description
inter-alpha-trypsin inhibitor heavy chain 2
See related
Ensembl:ENSOCUG00000004620
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
ITI-HC2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 16 NC_067389.1 (73275101..73318946, complement)

Chromosome 16 - NC_067389.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit gamma Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene prothymosin alpha Neighboring gene inter-alpha-trypsin inhibitor heavy chain 5 Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067389.1 Chromosome 16 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inter-alpha-trypsin inhibitor heavy chain H2
Names
inter-alpha-trypsin inhibitor heavy chain2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082647.2 → NP_001076116.1  inter-alpha-trypsin inhibitor heavy chain H2 precursor

    See identical proteins and their annotated locations for NP_001076116.1

    Status: PROVISIONAL

    Source sequence(s)
    AB050592
    UniProtKB/TrEMBL
    G1SM64, Q9GLY6
    Related
    ENSOCUP00000003991.3, ENSOCUT00000004625.4
    Conserved Domains (4) summary
    smart00609
    Location:56 → 185
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:307 → 488
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:80 → 629
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:736 → 921
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067389.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    73275101..73318946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008268046.3 → XP_008266268.1  inter-alpha-trypsin inhibitor heavy chain H2 isoform X1

    UniProtKB/TrEMBL
    G1SM64
    Related
    ENSOCUP00000042377.1
    Conserved Domains (4) summary
    smart00609
    Location:31 → 160
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:282 → 463
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:55 → 604
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:711 → 896
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
Nucleotide Protein
Heading Accession and Version

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