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rasa1a RAS p21 protein activator (GTPase activating protein) 1a [ Danio rerio (zebrafish) ]

Gene ID: 100002155, updated on 27-Mar-2024

Summary

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Official Symbol
rasa1aprovided by ZNC
Official Full Name
RAS p21 protein activator (GTPase activating protein) 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4694
See related
Ensembl:ENSDARG00000035535 AllianceGenome:ZFIN:ZDB-GENE-030131-4694
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rasa1; fd52c05; wu:fd52c05; si:dkey-195m1.3
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within blood vessel development and ephrin receptor signaling pathway. Is expressed in head. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See rasa1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (47862582..47968895)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (47210885..47317381)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108190109 Neighboring gene cytochrome c oxidase subunit 7C Neighboring gene uncharacterized LOC100150296 Neighboring gene cyclin H Neighboring gene transmembrane protein 161B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. Kawasaki J, et al. J Clin Invest, 2014 Jun. PMID 24837431, Free PMC Article
  2. Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Roberto VP, et al. Gene, 2015 Jul 15. PMID 25869932
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ephrin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
ras GTPase-activating protein 1
Names
RAS p21 protein activator 1
RAS p21 protein activator 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    47862582..47968895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301766.3 → XP_009300041.2  ras GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B2S6, F1R3X3
    Related
    ENSDARP00000051517.6, ENSDART00000051518.7

  2. XM_021476621.1 → XP_021332296.1  ras GTPase-activating protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q9R0
    Conserved Domains (6) summary
    cd08400
    Location:421 → 546
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10354
    Location:178 → 254
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:109 → 167
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:544 → 875
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:301 → 405
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl15255
    Location:7 → 92
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version

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