U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    EndoG Endonuclease G [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36309, updated on 4-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    EndoGprovided by FlyBase
    Official Full Name
    Endonuclease Gprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033690
    Locus tag
    Dmel_CG8862
    See related
    AllianceGenome:FB:FBgn0033690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8862; dEndoG; Dmel\CG8862; endoG; ENDOG
    Summary
    Enables endodeoxyribonuclease activity and endoribonuclease activity. Involved in ectopic germ cell programmed cell death; mitochondrion organization; and spermatid development. Predicted to be active in mitochondrial inner membrane and nucleus. Is expressed in several structures, including anterior endoderm anlage; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and endoderm. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    48E4-48E4; 2-66 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12177430..12178553, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8064935..8066058, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ornithine decarboxylase antizyme Neighboring gene antisense RNA:CR46194 Neighboring gene mir-281-2 stem loop Neighboring gene mir-281-1 stem loop Neighboring gene Chaperonin containing TCP1 subunit 5 Neighboring gene antisense RNA:CR45264 Neighboring gene uncharacterized protein Neighboring gene washout

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. Loll B, et al. Nucleic Acids Res, 2009 Nov. PMID 19783821, Free PMC Article
    2. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. Büttner S, et al. EMBO J, 2013 Nov 27. PMID 24129513, Free PMC Article
    3. Mitochondrial dynamics and inheritance during cell division, development and disease. Mishra P, et al. Nat Rev Mol Cell Biol, 2014 Oct. PMID 25237825, Free PMC Article
    4. Cellular inhibitor of apoptosis protein 1 ubiquitinates endonuclease G but does not affect endonuclease G-mediated cell death. Seo TW, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25139236
    5. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Wang W, et al. Nat Commun, 2021 Jan 20. PMID 33473107, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    endonuclease G
    Names
    CG8862-PA
    EndoG-PA
    NP_610737.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12177430..12178553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136893.4 → NP_610737.1  endonuclease G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JXB9
      Related
      FBpp0087120
      Conserved Domains (2) summary
      COG1864
      Location:39 → 305
      NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]
      cd00091
      Location:77 → 309
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXB9 Q7JXB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous