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    Epb41l3 erythrocyte membrane protein band 4.1 like 3 [ Mus musculus (house mouse) ]

    Gene ID: 13823, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Epb41l3provided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.1 like 3provided by MGI
    Primary source
    MGI:MGI:103008
    See related
    Ensembl:ENSMUSG00000024044 AllianceGenome:MGI:103008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4.1B; Dal1; NBL3; DAL1P; Epb4.1l3
    Summary
    Predicted to enable cytoskeletal protein-membrane anchor activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to paranode region of axon. Located in juxtaparanode region of axon; paranode region of axon; and postsynaptic density. Colocalizes with axolemma. Is expressed in several structures, including central nervous system; notochord; paraxial mesenchyme; and retina. Orthologous to human EPB41L3 (erythrocyte membrane protein band 4.1 like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 14.3), frontal lobe adult (RPKM 11.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.3; 17 40.15 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (69382642..69596986)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69075647..69289991)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36392 Neighboring gene STARR-seq mESC enhancer starr_43113 Neighboring gene STARR-seq mESC enhancer starr_43114 Neighboring gene STARR-seq mESC enhancer starr_43115 Neighboring gene predicted gene, 36437 Neighboring gene STARR-seq mESC enhancer starr_43116 Neighboring gene VISTA enhancer mm1658 Neighboring gene STARR-seq mESC enhancer starr_43119 Neighboring gene RIKEN cDNA 2410021H03 gene Neighboring gene STARR-seq mESC enhancer starr_43121 Neighboring gene STARR-seq mESC enhancer starr_43123 Neighboring gene STARR-seq mESC enhancer starr_43125 Neighboring gene predicted gene, 53973 Neighboring gene zinc finger and BTB domain containing 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein 4.1B Suppresses Tumor Metastasis by Regulating Epithelial-mesenchymal Transition Progression in Melanoma Cells. Wang C, et al. Int J Med Sci, 2019. PMID 31171904, Free PMC Article
    2. A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization. Wang J, et al. J Biol Chem, 2014 Feb 28. PMID 24381168, Free PMC Article
    3. Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer. Yi C, et al. Mol Cell Biol, 2005 Nov. PMID 16260618, Free PMC Article
    4. Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation. Kuns R, et al. Oncogene, 2005 Sep 29. PMID 16007173
    5. Immunohistochemical study of protein 4.1B in the normal and W/W(v) mouse seminiferous epithelium. Terada N, et al. J Histochem Cytochem, 2004 Jun. PMID 15150285

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data indicate that 4.1B is an important regulator during EMT progression in melanoma cells, which may present a potential target for the prevention and treatment of melanoma.
      Title: Protein 4.1B Suppresses Tumor Metastasis by Regulating Epithelial-mesenchymal Transition Progression in Melanoma Cells.
    2. This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6.
      Title: Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.
    3. findings document novel, isoform-selective roles for 130-kDa 4.1B in adhesion, spreading, and migration of MEF cells by affecting actin organization
      Title: A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization.
    4. The results of this study demonstrated that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness.
      Title: The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.
    5. in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber.
      Title: Protein 4.1B contributes to the organization of peripheral myelinated axons.
    6. Protein 4.1B plays a key role in ensuring the proper molecular compartmentalization of hemi-node-type region of axons of motor neurons.
      Title: Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.
    7. 4.1B plays a pivotal role in interactions between the paranodal AGSJs and axonal cytoskeleton.
      Title: The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.
    8. 4.1B was specifically and constantly expressed in the stereocilia tips during postnatal development.
      Title: Protein 4.1 expression in the developing hair cells of the mouse inner ear.
    9. In this study, the expression of 4.1B and its interaction with tumor suppressor in lung cancer-1 were examined in rodent adrenal gland, and the involvement of 4.1B in tumorigenesis
      Title: Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1.
    10. We propose that the 4.1B-containing membrane skeleton may play a role in regulating the Na(+) and HCO(3)(-) reabsorption in S1-S2 proximal tubules.
      Title: Interaction of membrane skeletal protein, protein 4.1B and p55, and sodium bicarbonate cotransporter1 in mouse renal S1-S2 proximal tubules.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein-membrane anchor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in paranodal junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in paranodal junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to juxtaparanode region of axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to paranode region of axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with axolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in paranode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    band 4.1-like protein 3
    Names
    DAL-1
    differentially expressed in adenocarcinoma of the lung protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355732.1 → NP_001342661.1  band 4.1-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151281, AC154761, BC079858
      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:421 → 467
      SAB; SAB domain
      pfam05902
      Location:681 → 786
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 330
      FA; FERM adjacent (FA)
      cl26557
      Location:507 → 641
      RNase_E_G; Ribonuclease E/G family

    2. NM_001355733.1 → NP_001342662.1  band 4.1-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151281, BC079858
      Consensus CDS
      CCDS89142.1
      UniProtKB/TrEMBL
      B6ZHD1, D0VYV6
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 586
      SAB; SAB domain
      pfam05902
      Location:798 → 903
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    3. NM_001355734.1 → NP_001342663.1  band 4.1-like protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC151281, BC079858
      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:732 → 778
      SAB; SAB domain
      pfam05902
      Location:992 → 1097
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)
      cl25865
      Location:4 → 82
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    4. NM_001355735.1 → NP_001342664.1  band 4.1-like protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC151281, BC079858
      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:714 → 760
      SAB; SAB domain
      pfam05902
      Location:974 → 1079
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)
      cl25865
      Location:4 → 82
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    5. NM_001355736.1 → NP_001342665.1  band 4.1-like protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151281, BC079858
      Consensus CDS
      CCDS28952.1
      UniProtKB/Swiss-Prot
      Q69ZT8, Q9R102, Q9WV92
      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:556 → 602
      SAB; SAB domain
      pfam05902
      Location:816 → 921
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)
      cl25865
      Location:4 → 82
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    6. NM_001424759.1 → NP_001411688.1  band 4.1-like protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC151281

    7. NM_001424760.1 → NP_001411689.1  band 4.1-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151281
      UniProtKB/TrEMBL
      D0VYV6

    8. NM_013813.2 → NP_038841.1  band 4.1-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_038841.1

      Status: VALIDATED

      Source sequence(s)
      AF152247, BC079858
      Consensus CDS
      CCDS28952.1
      UniProtKB/Swiss-Prot
      Q69ZT8, Q9R102, Q9WV92
      UniProtKB/TrEMBL
      B6ZHD1
      Related
      ENSMUSP00000079098.6, ENSMUST00000080208.7
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:556 → 602
      SAB; SAB domain
      pfam05902
      Location:816 → 921
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)
      cl25865
      Location:4 → 82
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      69382642..69596986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249482.1 → XP_030105342.1  band 4.1-like protein 3 isoform X16

      UniProtKB/TrEMBL
      A0A286YDY4
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK14949
      Location:566 → 863
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:617 → 663
      SAB; SAB domain
      pfam05902
      Location:875 → 980
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 330
      FA; FERM adjacent (FA)

    2. XM_017317239.2 → XP_017172728.1  band 4.1-like protein 3 isoform X37

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK10811
      Location:525 → 659
      rne; ribonuclease E; Reviewed
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:441 → 487
      SAB; SAB domain
      pfam05902
      Location:699 → 804
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 330
      FA; FERM adjacent (FA)

    3. XM_036160309.1 → XP_036016202.1  band 4.1-like protein 3 isoform X38

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK10811
      Location:525 → 659
      rne; ribonuclease E; Reviewed
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:439 → 487
      SAB; SAB domain
      pfam05902
      Location:699 → 777
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    4. XM_036160313.1 → XP_036016206.1  band 4.1-like protein 3 isoform X42

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK10811
      Location:491 → 618
      rne; ribonuclease E; Reviewed
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:439 → 487
      SAB; SAB domain
      pfam05902
      Location:658 → 736
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    5. XM_036160308.1 → XP_036016201.1  band 4.1-like protein 3 isoform X36

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK10811
      Location:529 → 663
      rne; ribonuclease E; Reviewed
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:443 → 491
      SAB; SAB domain
      pfam05902
      Location:703 → 808
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    6. XM_036160311.1 → XP_036016204.1  band 4.1-like protein 3 isoform X39

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK10811
      Location:507 → 641
      rne; ribonuclease E; Reviewed
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:421 → 469
      SAB; SAB domain
      pfam05902
      Location:681 → 759
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    7. XM_036160312.1 → XP_036016205.1  band 4.1-like protein 3 isoform X41

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      PRK10811
      Location:473 → 600
      rne; ribonuclease E; Reviewed
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:421 → 469
      SAB; SAB domain
      pfam05902
      Location:640 → 745
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    8. XM_030249487.2 → XP_030105347.1  band 4.1-like protein 3 isoform X25

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:558 → 604
      SAB; SAB domain
      pfam05902
      Location:816 → 894
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    9. XM_030249488.2 → XP_030105348.1  band 4.1-like protein 3 isoform X26

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:608 → 735
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:558 → 604
      SAB; SAB domain
      pfam05902
      Location:775 → 880
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    10. XM_030249472.1 → XP_030105332.1  band 4.1-like protein 3 isoform X2

      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:737 → 784
      SAB; SAB domain
      pfam05902
      Location:1294 → 1399
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    11. XM_036160302.1 → XP_036016195.1  band 4.1-like protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:766 → 893
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:714 → 762
      SAB; SAB domain
      pfam05902
      Location:933 → 1011
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    12. XM_006523612.4 → XP_006523675.1  band 4.1-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006523675.1

      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:755 → 802
      SAB; SAB domain
      pfam05902
      Location:1312 → 1417
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    13. XM_030249489.1 → XP_030105349.1  band 4.1-like protein 3 isoform X27

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:630 → 764
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:545 → 592
      SAB; SAB domain
      pfam05902
      Location:804 → 882
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    14. XM_030249492.1 → XP_030105352.1  band 4.1-like protein 3 isoform X33

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:596 → 723
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:545 → 592
      SAB; SAB domain
      pfam05902
      Location:763 → 841
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    15. XM_030249491.1 → XP_030105351.1  band 4.1-like protein 3 isoform X32

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:612 → 739
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:561 → 608
      SAB; SAB domain
      pfam05902
      Location:779 → 857
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    16. XM_030249490.1 → XP_030105350.1  band 4.1-like protein 3 isoform X29

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 586
      SAB; SAB domain
      pfam05902
      Location:798 → 876
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    17. XM_036160306.1 → XP_036016199.1  band 4.1-like protein 3 isoform X31

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:578 → 705
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:527 → 574
      SAB; SAB domain
      pfam05902
      Location:745 → 850
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    18. XM_030249494.1 → XP_030105354.1  band 4.1-like protein 3 isoform X35

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Related
      ENSMUSP00000156827.2, ENSMUST00000233964.2
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:578 → 705
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:527 → 574
      SAB; SAB domain
      pfam05902
      Location:745 → 823
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    19. XM_030249495.1 → XP_030105355.1  band 4.1-like protein 3 isoform X40

      UniProtKB/TrEMBL
      D0VYV7
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:499 → 641
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:681 → 759
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    20. XM_006523613.4 → XP_006523676.1  band 4.1-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006523676.1

      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:755 → 802
      SAB; SAB domain
      pfam05902
      Location:1312 → 1417
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    21. XM_017317238.2 → XP_017172727.1  band 4.1-like protein 3 isoform X28

      UniProtKB/TrEMBL
      A0A3B2WBE1, A7YY80
      Related
      ENSMUSP00000153228.2, ENSMUST00000225977.2
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:596 → 723
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:545 → 592
      SAB; SAB domain
      pfam05902
      Location:763 → 868
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    22. XM_017317227.3 → XP_017172716.1  band 4.1-like protein 3 isoform X2

      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:737 → 784
      SAB; SAB domain
      pfam05902
      Location:1294 → 1399
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    23. XM_011246283.1 → XP_011244585.1  band 4.1-like protein 3 isoform X5

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:806 → 933
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:755 → 802
      SAB; SAB domain
      pfam05902
      Location:973 → 1078
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    24. XM_030249478.1 → XP_030105338.1  band 4.1-like protein 3 isoform X8

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:806 → 933
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:755 → 802
      SAB; SAB domain
      pfam05902
      Location:973 → 1051
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    25. XM_030249477.1 → XP_030105337.1  band 4.1-like protein 3 isoform X6

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:734 → 780
      SAB; SAB domain
      pfam05902
      Location:992 → 1070
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    26. XM_036160299.1 → XP_036016192.1  band 4.1-like protein 3 isoform X7

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:784 → 911
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:732 → 780
      SAB; SAB domain
      pfam05902
      Location:951 → 1056
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    27. XM_030249475.1 → XP_030105335.1  band 4.1-like protein 3 isoform X3

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:721 → 768
      SAB; SAB domain
      pfam05902
      Location:1005 → 1110
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    28. XM_030249476.1 → XP_030105336.1  band 4.1-like protein 3 isoform X4

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:721 → 768
      SAB; SAB domain
      pfam05902
      Location:980 → 1085
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    29. XM_011246285.1 → XP_011244587.1  band 4.1-like protein 3 isoform X11

      UniProtKB/TrEMBL
      D0VYV7
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:697 → 835
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:875 → 980
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    30. XM_030249480.1 → XP_030105340.1  band 4.1-like protein 3 isoform X12

      UniProtKB/TrEMBL
      B6ZHD1
      Related
      ENSMUSP00000108300.2, ENSMUST00000112680.8
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:579 → 626
      SAB; SAB domain
      pfam05902
      Location:838 → 943
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    31. XM_036160305.1 → XP_036016198.1  band 4.1-like protein 3 isoform X22

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:608 → 735
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:556 → 604
      SAB; SAB domain
      pfam05902
      Location:775 → 853
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    32. XM_017317231.1 → XP_017172720.1  band 4.1-like protein 3 isoform X14

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:545 → 592
      SAB; SAB domain
      pfam05902
      Location:829 → 934
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    33. XM_017317232.1 → XP_017172721.1  band 4.1-like protein 3 isoform X18

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:545 → 592
      SAB; SAB domain
      pfam05902
      Location:829 → 907
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    34. XM_030249483.1 → XP_030105343.1  band 4.1-like protein 3 isoform X17

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:545 → 592
      SAB; SAB domain
      pfam05902
      Location:804 → 909
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    35. XM_011246290.1 → XP_011244592.1  band 4.1-like protein 3 isoform X30

      UniProtKB/TrEMBL
      A0A3B2WD96, D0VYV7
      Related
      ENSMUSP00000156921.2, ENSMUST00000232706.2
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:517 → 659
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:699 → 804
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    36. XM_036160307.1 → XP_036016200.1  band 4.1-like protein 3 isoform X34

      UniProtKB/TrEMBL
      D0VYV7
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:517 → 659
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:699 → 777
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    37. XM_036160300.1 → XP_036016193.1  band 4.1-like protein 3 isoform X9

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:766 → 893
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:714 → 762
      SAB; SAB domain
      pfam05902
      Location:933 → 1038
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    38. XM_030249481.1 → XP_030105341.1  band 4.1-like protein 3 isoform X15

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 586
      SAB; SAB domain
      pfam05902
      Location:823 → 928
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    39. XM_036160304.1 → XP_036016197.1  band 4.1-like protein 3 isoform X21

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:590 → 717
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:538 → 586
      SAB; SAB domain
      pfam05902
      Location:757 → 862
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 449
      FA; FERM adjacent (FA)

    40. XM_030249486.1 → XP_030105346.1  band 4.1-like protein 3 isoform X24

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:590 → 717
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 586
      SAB; SAB domain
      pfam05902
      Location:757 → 835
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    41. XM_030249484.1 → XP_030105344.1  band 4.1-like protein 3 isoform X20

      UniProtKB/TrEMBL
      A0A3B2WBE1
      Conserved Domains (6) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      PRK10811
      Location:637 → 771
      rne; ribonuclease E; Reviewed
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:527 → 574
      SAB; SAB domain
      pfam05902
      Location:811 → 889
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)

    42. XM_017317234.1 → XP_017172723.1  band 4.1-like protein 3 isoform X19

      UniProtKB/TrEMBL
      B6ZHD1
      Conserved Domains (5) summary
      smart00295
      Location:120 → 309
      B41; Band 4.1 homologues
      cd13184
      Location:304 → 397
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:527 → 574
      SAB; SAB domain
      pfam05902
      Location:786 → 891
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:406 → 447
      FA; FERM adjacent (FA)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV92.1 GenPept UniProtKB/Swiss-Prot:Q9WV92

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