Flot2 flotillin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flot2provided by MGI
Official Full Name: flotillin 2provided by MGI
Primary source: MGI:MGI:103309
See related: Ensembl:ENSMUSG00000061981 AllianceGenome:MGI:103309
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Esa; reggie-2
Summary: Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in anterograde dendritic transport and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within regulation of myoblast differentiation. Located in acrosomal membrane and caveola. Part of flotillin complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 67.2), mammary gland adult (RPKM 55.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (77928757..77951260)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78037931..78060434)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock.
Title: Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock.
Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
Title: Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
Flot2 lipid rafts are associated with Fyn, and that Fyn phosphorylates Flot2 during neural differentiation of P19C6 cells.
Title: The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells.
the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported.
Title: Flotillins in the intercalated disc are potential modulators of cardiac excitability.
This study suggests that reggie-1 and reggie-2 function at Rab11a recycling containers in the transport of PSD-95, N-cadherin, GluA1 and GluN1, and promote (together with significant signaling molecules) spine-directed trafficking, spine synapse formation and the in vitro correlate of LTP.
Title: Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons.
These results indicated that miR-124 could potentially play a role in caveolin-independent vesicle trafficking and modulation of flotillin-2 expression in mouse acrosome biogenesis.
Title: Expression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis.
The role of flotillin 1 and flotillin 2 in regulating amyloid beta production in a mouse model of cerebral amyloidosis, remains unlear.
Title: The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice.
Curcumin mediates neurite outgrowth through activation of the reggie-1 pathway.
Title: Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons.
The genetic ablation of flotillin-2 in a mouse model or its knockdown in cultured cells increases extracellular signal regulated kinase (ERK) activation.
Title: Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.
upregulation of reggie-1 in mammalian neurons provides nerve cells with neuron-intrinsic properties required for axon growth and successful regeneration
Title: Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Flot2 (e-PCR), detects polymorphism
- UniSTS:143117

AI573412 (e-PCR)
- UniSTS:163508

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane raft	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
part_of flotillin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of flotillin complex	IDA Inferred from Direct Assay more info	PubMed
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in uropod	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: flotillin-2

Names: epidermal surface antigen; membrane component chromosome 17 surface marker 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040403.2 → NP_001035493.1 flotillin-2 isoform 1

See identical proteins and their annotated locations for NP_001035493.1

Status: VALIDATED

Source sequence(s)

AL669840, BC070423, BY204171, CD774654

Consensus CDS

CCDS36237.1

UniProtKB/Swiss-Prot

Q5SS82, Q60634, Q6NS75

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Related

ENSMUSP00000072136.6, ENSMUST00000072289.12

Conserved Domains (2) summary

COG2268
Location:6 → 417

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:34 → 178

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001284227.2 → NP_001271156.1 flotillin-2 isoform 3

See identical proteins and their annotated locations for NP_001271156.1

Status: VALIDATED

Source sequence(s)

AK149530, AL669840, BC070423, BY195482, CD774654

UniProtKB/TrEMBL

Q3UEG9, Q8CDE0, Q9DC36

Conserved Domains (3) summary

smart00244
Location:115 → 297

PHB; prohibitin homologues

cd03399
Location:72 → 206

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:341 → 415

Flot; Flotillin
NM_001284228.3 → NP_001271157.1 flotillin-2 isoform 2

See identical proteins and their annotated locations for NP_001271157.1

Status: VALIDATED

Source sequence(s)

AL669840, BC070423, CD774654, U07890

Consensus CDS

CCDS25088.1

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Related

ENSMUST00000136353.2

Conserved Domains (2) summary

COG2268
Location:1 → 368

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:1 → 129

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001362625.1 → NP_001349554.1 flotillin-2 isoform 5

Status: VALIDATED

Source sequence(s)

AL669840, CD774654

Consensus CDS

CCDS88200.1

UniProtKB/TrEMBL

Q5SS83, Q8CDE0, Q9DC36

Related

ENSMUSP00000073342.7, ENSMUST00000073660.7

Conserved Domains (2) summary

COG2268
Location:6 → 417

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:34 → 178

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001362626.1 → NP_001349555.1 flotillin-2 isoform 2

Status: VALIDATED

Source sequence(s)

AL669840, CD774654

Consensus CDS

CCDS25088.1

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Conserved Domains (2) summary

COG2268
Location:1 → 368

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:1 → 129

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001362627.1 → NP_001349556.1 flotillin-2 isoform 4

Status: VALIDATED

Source sequence(s)

AL669840, CD774654

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Conserved Domains (2) summary

COG2268
Location:8 → 340

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:1 → 101

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_008028.4 → NP_032054.1 flotillin-2 isoform 2

See identical proteins and their annotated locations for NP_032054.1

Status: VALIDATED

Source sequence(s)

AK149530, AL669840, BC070423, BY195482, CD774654

Consensus CDS

CCDS25088.1

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Related

ENSMUSP00000098347.3, ENSMUST00000100784.9

Conserved Domains (2) summary

COG2268
Location:1 → 368

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:1 → 129

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

77928757..77951260

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245558.1 → XP_030101418.1 flotillin-2 isoform X3

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Conserved Domains (2) summary

COG2268
Location:8 → 340

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:1 → 101

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
XM_030245557.2 → XP_030101417.1 flotillin-2 isoform X1

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Conserved Domains (2) summary

COG2268
Location:7 → 380

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:7 → 141

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
XM_036156327.1 → XP_036012220.1 flotillin-2 isoform X2

UniProtKB/TrEMBL

Q8CDE0, Q9DC36

Conserved Domains (2) summary

COG2268
Location:1 → 368

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:1 → 129

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily