Fasn fatty acid synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fasnprovided by MGI
Official Full Name: fatty acid synthaseprovided by MGI
Primary source: MGI:MGI:95485
See related: Ensembl:ENSMUSG00000025153 AllianceGenome:MGI:95485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FAS; A630082H08Rik
Summary: Enables fatty acid synthase activity. Involved in ether lipid biosynthetic process; mammary gland development; and myeloid leukocyte differentiation. Acts upstream of or within cellular response to interleukin-4; epithelial cell development; and fatty acid biosynthetic process. Located in glycogen granule. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; sensory organ; and skeleton. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 1605.0), subcutaneous fat pad adult (RPKM 1125.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.56 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120696784..120715992, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120805958..120825166, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase.
Title: TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase.
Proteolytic activation of fatty acid synthase signals pan-stress resolution.
Title: Proteolytic activation of fatty acid synthase signals pan-stress resolution.
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Title: Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Title: BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis.
Title: High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis.
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
Title: Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.
Title: CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.
Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD.
Title: Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD.
Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice.
Title: Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Title: TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P10 (e-PCR)
- UniSTS:271369

Fasn (e-PCR), detects polymorphism
- UniSTS:506890

PMC207565P2 (e-PCR)
- UniSTS:271952

Fasn (e-PCR), detects polymorphism
- UniSTS:461915

PMC164451P1 (e-PCR)
- UniSTS:271485

Fasn (e-PCR), detects polymorphism
- UniSTS:546767

PMC166350P1 (e-PCR)
- UniSTS:271584

PMC166350P3 (e-PCR)
- UniSTS:271585

Fasn (e-PCR), detects polymorphism
- UniSTS:143075

NoName (e-PCR)
- UniSTS:225262

NoName (e-PCR)
- UniSTS:236790

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables S-malonyltransferase activity	IEA Inferred from Electronic Annotation more info
enables [acyl-carrier-protein] S-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables [acyl-carrier-protein] S-malonyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fatty acid synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid synthase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid synthase activity	TAS Traceable Author Statement more info	PubMed
enables fatty acyl-[ACP] hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of endothelial intestinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ether lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glandular epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glycogen granule	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fatty acid synthase

Names: type I Fatty Acid Synthase

NP_032014.3

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

XP_030101416.1

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007988.3 → NP_032014.3 fatty acid synthase

See identical proteins and their annotated locations for NP_032014.3

Status: VALIDATED

Source sequence(s)

AF127033, AK078721, AK080374, AK147694, CJ125823

Consensus CDS

CCDS25759.1

UniProtKB/Swiss-Prot

B1ATU8, P19096, Q6PB72, Q8C4Z0, Q9EQR0

UniProtKB/TrEMBL

Q3UHT6

Related

ENSMUSP00000052872.8, ENSMUST00000055655.9

Conserved Domains (9) summary

cd08954
Location:1869 → 2105

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2118 → 2173

PKS_PP; Phosphopantetheine attachment site

smart00829
Location:1557 → 1847

PKS_ER; Enoylreductase

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 809

Acyl_transf_1; Acyl transferase domain

pfam08242
Location:1239 → 1336

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 472

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1109

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

cl21494
Location:2235 → 2494

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

120696784..120715992 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245556.1 → XP_030101416.1 fatty acid synthase isoform X1

UniProtKB/Swiss-Prot

B1ATU8, P19096, Q6PB72, Q8C4Z0, Q9EQR0

UniProtKB/TrEMBL

Q3UHT6

Related

ENSMUSP00000145585.2, ENSMUST00000206589.2

Conserved Domains (9) summary

cd08954
Location:1869 → 2105

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2118 → 2173

PKS_PP; Phosphopantetheine attachment site

smart00829
Location:1557 → 1847

PKS_ER; Enoylreductase

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 809

Acyl_transf_1; Acyl transferase domain

pfam08242
Location:1239 → 1336

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 472

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1109

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

cl21494
Location:2235 → 2494

Abhydrolase; alpha/beta hydrolases