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    Tmem65 transmembrane protein 65 [ Mus musculus (house mouse) ]

    Gene ID: 74868, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem65provided by MGI
    Official Full Name
    transmembrane protein 65provided by MGI
    Primary source
    MGI:MGI:1922118
    See related
    Ensembl:ENSMUSG00000062373 AllianceGenome:MGI:1922118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610029O13Rik; 4930438D12Rik
    Summary
    Involved in cardiac ventricle development and regulation of cardiac conduction. Located in intercalated disc and plasma membrane. Orthologous to human TMEM65 (transmembrane protein 65). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 30.6), cerebellum adult (RPKM 15.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem65 in Genome Data Viewer
    Location:
    15 D1; 15 25.09 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58654118..58695510, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58782269..58823663, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene fer-1 like family member 6 Neighboring gene STARR-seq mESC enhancer starr_38758 Neighboring gene predicted gene, 36451 Neighboring gene STARR-seq mESC enhancer starr_38759 Neighboring gene predicted gene, 41329 Neighboring gene STARR-positive B cell enhancer ABC_E5480 Neighboring gene predicted gene, 24041 Neighboring gene STARR-positive B cell enhancer ABC_E3141 Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts. Teng ACT, et al. Nat Commun, 2022 Oct 18. PMID 36257954, Free PMC Article
    2. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Sharma P, et al. Nat Commun, 2015 Sep 25. PMID 26403541
    3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    4. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
      Title: Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
    2. Tmem65 is an intercalated disc protein that interacts with and functionally regulates ventricular Cx43.
      Title: Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiac ventricle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175212.4 → NP_780421.2  transmembrane protein 65

      See identical proteins and their annotated locations for NP_780421.2

      Status: PROVISIONAL

      Source sequence(s)
      AC107772
      Consensus CDS
      CCDS27493.1
      UniProtKB/Swiss-Prot
      Q4VAE3, Q810S8
      Related
      ENSMUSP00000071984.6, ENSMUST00000072113.6
      Conserved Domains (1) summary
      pfam10507
      Location:114 → 221
      DUF2453; Protein of unknown function (DUF2453)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58654118..58695510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521504.5 → XP_006521567.1  transmembrane protein 65 isoform X1

      Conserved Domains (1) summary
      pfam10507
      Location:141 → 248
      TMEM65; Transmembrane protein 65

    2. XM_036159621.1 → XP_036015514.1  transmembrane protein 65 isoform X2

      Conserved Domains (1) summary
      pfam10507
      Location:36 → 143
      TMEM65; Transmembrane protein 65

    3. XM_011245759.4 → XP_011244061.1  transmembrane protein 65 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VAE3.1 GenPept UniProtKB/Swiss-Prot:Q4VAE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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