U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Txlna taxilin alpha [ Mus musculus (house mouse) ]

    Gene ID: 109658, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Txlnaprovided by MGI
    Official Full Name
    taxilin alphaprovided by MGI
    Primary source
    MGI:MGI:105968
    See related
    Ensembl:ENSMUSG00000053841 AllianceGenome:MGI:105968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il14; Txln; 2600010N21Rik
    Summary
    Predicted to enable syntaxin binding activity. Acts upstream of or within B cell activation. Predicted to be located in cytoplasm. Is expressed in brain; metanephros; oviduct; spinal cord; and testis. Orthologous to human TXLNA (taxilin alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 25.6), CNS E11.5 (RPKM 25.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129519870..129534867, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129626077..129641065, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene IQ motif containing C Neighboring gene coiled coil domain containing 28B Neighboring gene predicted gene, 34305 Neighboring gene STARR-positive B cell enhancer ABC_E1283 Neighboring gene karyopherin subunit alpha 6 Neighboring gene STARR-positive B cell enhancer ABC_E7992 Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells. Dong YS, et al. Cell Death Differ, 2016 May. PMID 26494466, Free PMC Article
    2. Characteristics of a novel monoclonal antibody against interleukin-14alpha. Peng X, et al. Hybridoma (Larchmt), 2009 Aug. PMID 19663695
    3. IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans. Shen L, et al. Clin Immunol, 2009 Mar. PMID 19038581
    4. IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. Le Goff L, et al. Int J Parasitol, 2002 Sep. PMID 12204227
    5. Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway. Jin X, et al. Aging Cell, 2020 Oct. PMID 32840323, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
      Title: Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
    2. The TXLNA may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs in response to testicular injury.
      Title: Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells.
    3. analysis of a novel monoclonal antibody against interleukin-14alpha
      Title: Characteristics of a novel monoclonal antibody against interleukin-14alpha.
    4. Transgenic mice in which IL-14a expression was increased constitutively develop all the clinical and immunological features of primary Sjogren's disease in the same relative time frame as patients with primary Sjogren's disease
      Title: IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC77972, MGC86145

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-taxilin
    Names
    interleukin 14
    taxilin Txln

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005506.3 → NP_001005506.2  alpha-taxilin

      See identical proteins and their annotated locations for NP_001005506.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK168418, AW121192, BC060227
      Consensus CDS
      CCDS38887.1
      UniProtKB/Swiss-Prot
      Q6P1E5, Q6PAM1
      UniProtKB/TrEMBL
      Q3UD58
      Related
      ENSMUSP00000081285.6, ENSMUST00000084264.12
      Conserved Domains (1) summary
      pfam09728
      Location:170 → 477
      Taxilin; Myosin-like coiled-coil protein

    2. NM_001199695.1 → NP_001186624.1  alpha-taxilin

      See identical proteins and their annotated locations for NP_001186624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK150240, AW121192, CJ151043
      Consensus CDS
      CCDS38887.1
      UniProtKB/Swiss-Prot
      Q6P1E5, Q6PAM1
      UniProtKB/TrEMBL
      Q3UD58
      Related
      ENSMUSP00000042153.10, ENSMUST00000046425.16
      Conserved Domains (1) summary
      pfam09728
      Location:170 → 477
      Taxilin; Myosin-like coiled-coil protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129519870..129534867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502659.5 → XP_006502722.1  alpha-taxilin isoform X1

      See identical proteins and their annotated locations for XP_006502722.1

      UniProtKB/Swiss-Prot
      Q6P1E5, Q6PAM1
      UniProtKB/TrEMBL
      Q3UD58
      Conserved Domains (1) summary
      pfam09728
      Location:170 → 477
      Taxilin; Myosin-like coiled-coil protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PAM1.1 GenPept UniProtKB/Swiss-Prot:Q6PAM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous