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    Qars1 glutaminyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 97541, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Qars1provided by MGI
    Official Full Name
    glutaminyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:1915851
    See related
    Ensembl:ENSMUSG00000032604 AllianceGenome:MGI:1915851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Qars; GLNRS; 1110018N24Rik; 1200016L19Rik
    Summary
    Predicted to enable several functions, including glutamine-tRNA ligase activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in several processes, including glutaminyl-tRNA aminoacylation; negative regulation of nitrogen compound metabolic process; and negative regulation of signal transduction. Predicted to act upstream of or within negative regulation of apoptotic process. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 47.6), placenta adult (RPKM 34.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F2; 9 59.44 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108385204..108393140)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108508005..108515941)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene laminin, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutamine-rich 1 Neighboring gene STARR-positive B cell enhancer ABC_E3861 Neighboring gene inosine monophosphate dehydrogenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Zhang X, et al. Am J Hum Genet, 2014 Apr 3. PMID 24656866, Free PMC Article
    2. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Kim JY, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060739, Free PMC Article
    3. Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Chen J, et al. Genes Dev, 2011 Apr 1. PMID 21460039, Free PMC Article
    4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105238

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamine--tRNA ligase
    Names
    glutamine-tRNA ligase
    NP_598555.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133794.2 → NP_598555.2  glutamine--tRNA ligase

      See identical proteins and their annotated locations for NP_598555.2

      Status: VALIDATED

      Source sequence(s)
      AK155759, BY131964, CT010508
      Consensus CDS
      CCDS23530.1
      UniProtKB/Swiss-Prot
      Q3TN94, Q8BML9, Q8BU21
      UniProtKB/TrEMBL
      Q3TIN2
      Related
      ENSMUSP00000006838.9, ENSMUST00000006838.16
      Conserved Domains (1) summary
      cl27212
      Location:2 → 774
      GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108385204..108393140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001168270.1: Suppressed sequence

      Description
      NM_001168270.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BML9.1 GenPept UniProtKB/Swiss-Prot:Q8BML9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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