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    Pi15 peptidase inhibitor 15 [ Mus musculus (house mouse) ]

    Gene ID: 94227, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pi15provided by MGI
    Official Full Name
    peptidase inhibitor 15provided by MGI
    Primary source
    MGI:MGI:1934659
    See related
    Ensembl:ENSMUSG00000067780 AllianceGenome:MGI:1934659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P24TI; P25TI; PI-15; SugarCrisp
    Summary
    Predicted to enable peptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in glomerular tuft; renal cortex; s-shaped body; visceral epithelium of capillary loop renal corpuscle; and visceral epithelium of mature renal corpuscle. Orthologous to human PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 1.8), genital fat pad adult (RPKM 1.2) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A3; 1 5.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (17672064..17701169)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (17601901..17630939)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00359 Neighboring gene peptidylprolyl isomerase A pseudogene 1_125.1 Neighboring gene STARR-seq mESC enhancer starr_00360 Neighboring gene STARR-seq mESC enhancer starr_00361 Neighboring gene STARR-seq mESC enhancer starr_00362 Neighboring gene STARR-seq mESC enhancer starr_00364 Neighboring gene predicted gene, 25166 Neighboring gene predicted gene 28154 Neighboring gene STARR-seq mESC enhancer starr_00366 Neighboring gene predicted gene 16070 Neighboring gene cysteine-rich secretory protein LCCL domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_00368 Neighboring gene high mobility group box transcription factor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo. Smith DM, et al. Mech Dev, 2001 Apr. PMID 11287197
    2. Large-scale identification of genes implicated in kidney glomerulus development and function. Takemoto M, et al. EMBO J, 2006 Mar 8. PMID 16498405, Free PMC Article
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidase inhibitor 15
    Names
    cysteine-rich secreted protein
    protease inhibitor 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053191.5 → NP_444421.3  peptidase inhibitor 15 precursor

      Status: VALIDATED

      Source sequence(s)
      AC104917
      Consensus CDS
      CCDS48225.1
      UniProtKB/Swiss-Prot
      Q3TN14, Q8BS03, Q99MM7
      Related
      ENSMUSP00000085826.3, ENSMUST00000088476.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      17672064..17701169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154509.1 → XP_036010402.1  peptidase inhibitor 15 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J126
      Conserved Domains (1) summary
      cd18814
      Location:78 → 223
      CAP_PI15; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BS03.2 GenPept UniProtKB/Swiss-Prot:Q8BS03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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