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    Gna15 G protein subunit alpha 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89788, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gna15provided by RGD
    Official Full Name
    G protein subunit alpha 15provided by RGD
    Primary source
    RGD:619751
    See related
    Ensembl:ENSRNOG00000005378 AllianceGenome:RGD:619751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg1l
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Located in membrane. Orthologous to human GNA15 (G protein subunit alpha 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 56.8), Thymus (RPKM 32.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8835396..8856269)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8184632..8205508)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11054249..11075152)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene G protein subunit alpha 11 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene nicalin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Kusakabe Y, et al. Biochim Biophys Acta, 1998 Jul 24. PMID 9685675
    2. Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice. Davignon I, et al. Mol Cell Biol, 2000 Feb. PMID 10629036, Free PMC Article
    3. Regulation of phosphoinositide-specific phospholipase C. Rhee SG. Annu Rev Biochem, 2001. PMID 11395409, Free PMC Article
    4. Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15. Feild JA, et al. FEBS Lett, 1999 Oct 22. PMID 10571060
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein subunit alpha-15
    Names
    g alpha-15
    guanine nucleotide binding protein, alpha 15
    heterotrimeric guanine nucleotide-binding protein 1l

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053542.2 → NP_445994.2  guanine nucleotide-binding protein subunit alpha-15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O88302
      UniProtKB/TrEMBL
      A6K873, G3V6N8
      Related
      ENSRNOP00000007202.2, ENSRNOT00000007202.5
      Conserved Domains (1) summary
      cd00066
      Location:43 → 368
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8835396..8856269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264349.1 → XP_063120419.1  guanine nucleotide-binding protein subunit alpha-15 isoform X2

    2. XM_063264350.1 → XP_063120420.1  guanine nucleotide-binding protein subunit alpha-15 isoform X3

    3. XM_006241021.5 → XP_006241083.1  guanine nucleotide-binding protein subunit alpha-15 isoform X1

      UniProtKB/Swiss-Prot
      O88302
      Conserved Domains (2) summary
      cd00066
      Location:43 → 367
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:22 → 371
      G_alpha; G protein alpha subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88302.1 GenPept UniProtKB/Swiss-Prot:O88302

    Gene LinkOut

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