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    CKA2 casein kinase II, alpha chain 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824162, updated on 7-Sep-2023

    Summary

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    Gene symbol
    CKA2
    Gene description
    casein kinase II, alpha chain 2
    Primary source
    Araport:AT3G50000
    Locus tag
    AT3G50000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''casein kinase II; alpha chain 2; ALPHA CHAIN 2; alpha chain 2''; ATCKA2; ATPK15D; casein kinase II; CASEIN KINASE II
    Summary
    Encodes the casein kinase II (CK2) catalytic subunit (alpha).
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (18534450..18537073)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Low temperature viability protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Serine protease inhibitor, potato inhibitor I-type family protein Neighboring gene ARM-repeat/Tetratricopeptide repeat (TPR)-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway. Wei P, et al. Plant Cell, 2021 May 31. PMID 33793856
    2. A dominant negative mutant of protein kinase CK2 exhibits altered auxin responses in Arabidopsis. Marquès-Bueno MM, et al. Plant J, 2011 Jul. PMID 21435053
    3. CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis. Zhu J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36546827, Free PMC Article
    4. TCO, a Putative Transcriptional Regulator in Arabidopsis, Is a Target of the Protein Kinase CK2. Weinman LM, et al. Int J Mol Sci, 2018 Dec 28. PMID 30597831, Free PMC Article
    5. The Protein Kinase CK2 Mediates Cross-Talk between Auxin- and Salicylic Acid-Signaling Pathways in the Regulation of PINOID Transcription. Armengot L, et al. PLoS One, 2016. PMID 27275924, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.
      Title: CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.
    2. Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
      Title: Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
    3. CK2 also plays a key role in the transcriptional regulation of PINOID (PID), an AGC protein kinase that modulates the apical/basal localization of auxin-efflux transporters.
      Title: The Protein Kinase CK2 Mediates Cross-Talk between Auxin- and Salicylic Acid-Signaling Pathways in the Regulation of PINOID Transcription.
    4. CK2 activity increases the roots endogenous salicylic acid levels, indicating that CK2 activity is required for SA biosynthesis.CK2 is transcriptionally regulated by salicylic acid.
      Title: Functional interplay between protein kinase CK2 and salicylic acid sustains PIN transcriptional expression and root development.
    5. CK2 alpha subunits affect diverse developmental and stress responsive pathways in Arabidopsis.
      Title: Casein kinase II α subunits affect multiple developmental and stress-responsive pathways in Arabidopsis.
    6. CK2 is required in the maintenance and control of genomic stability and chromatin structure in plants, and that this process affects several functions, including the DNA damage response and DNA repair.[CK2]
      Title: CK2-defective Arabidopsis plants exhibit enhanced double-strand break repair rates and reduced survival after exposure to ionizing radiation.
    7. CK2 activity depletion affects auxin-dependent processes, and particularly auxin transport.
      Title: A dominant negative mutant of protein kinase CK2 exhibits altered auxin responses in Arabidopsis.
    8. The effects of a cka1a2a3 triple mutant on the Arabidopsis (Arabidopsis thaliana) circadian clock, were examined.
      Title: A role for protein kinase casein kinase2 α-subunits in the Arabidopsis circadian clock.
    9. alpha1 and alpha2 subunits of CK2 individually phosphorylated phytochrome interacting factors weakly in vitro.
      Title: Phosphorylation by CK2 enhances the rapid light-induced degradation of phytochrome interacting factor 1 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114860.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-C IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    casein kinase II, alpha chain 2
    NP_190569.2
    • ''casein kinase II, alpha chain 2'' (CKA2); FUNCTIONS IN: protein binding, kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: casein kinase alpha 1 (TAIR:AT5G67380.1); Has 86321 Blast hits to 85419 proteins in 2558 species: Archae - 72; Bacteria - 9686; Metazoa - 32978; Fungi - 11348; Plants - 15028; Viruses - 319; Other Eukaryotes - 16890 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18534450..18537073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114860.4 → NP_190569.2  casein kinase II, alpha chain 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190569.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q08466, Q8H120, Q8H765, Q9SN18
      UniProtKB/TrEMBL
      A0A178VIQ4, A0A5S9XJF1
      Conserved Domains (2) summary
      cd14132
      Location:85 → 389
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
      pfam00069
      Location:104 → 389
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08466.3

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