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    Kmt5a lysine methyltransferase 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689820, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Kmt5aprovided by RGD
    Official Full Name
    lysine methyltransferase 5Aprovided by RGD
    Primary source
    RGD:1587560
    See related
    Ensembl:ENSRNOG00000064318 AllianceGenome:RGD:1587560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Setd8; Pr-set7; RGD1305893
    Summary
    Predicted to enable histone-lysine N-methyltransferase activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be located in cytosol and nucleoplasm. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 143.0), Adrenal (RPKM 141.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kmt5a in Genome Data Viewer
    Location:
    12q15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37800339..37823706, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32139353..32167777, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37558150..37581183, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 35 Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene strawberry notch homolog 1 Neighboring gene cyclin-dependent kinase 2 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury. Li X, et al. Mediators Inflamm, 2023. PMID 36936537, Free PMC Article
    2. Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat. Barrett E, et al. Reprod Sci, 2021 May. PMID 33398850, Free PMC Article
    3. Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration. Pan C, et al. PLoS One, 2012. PMID 22720056, Free PMC Article
    4. Targeting protein lysine methylation and demethylation in cancers. He Y, et al. Acta Biochim Biophys Sin (Shanghai), 2012 Jan. PMID 22194015, Free PMC Article
    5. Modulation of p53 function by SET8-mediated methylation at lysine 382. Shi X, et al. Mol Cell, 2007 Aug 17. PMID 17707234, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
      Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
    2. Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.
      Title: Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.
    3. Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARgamma-KMT5A Axis in the Rat.
      Title: Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H4K20 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K20 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K20 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in polytene chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-lysine methyltransferase KMT5A
    Names
    N-lysine methyltransferase SETD8
    SET domain containing (lysine methyltransferase) 8
    SET domain-containing 8
    histone methyltransferase Pr-set7/Set8
    histone-lysine N-methyltransferase SETD8
    lysine (K)-specific methyltransferase 5A
    NP_001233594.2
    NP_001400566.1
    XP_006249390.1
    XP_006249392.1
    XP_017453947.1
    XP_038945699.1
    XP_038945701.1
    XP_063127745.1
    XP_063127746.1
    XP_063127747.1
    XP_063127749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001246665.2 → NP_001233594.2  N-lysine methyltransferase KMT5A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZY89
      Related
      ENSRNOP00000084143.1, ENSRNOT00000106166.1

    2. NM_001413637.1 → NP_001400566.1  N-lysine methyltransferase KMT5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6GKG3
      Related
      ENSRNOP00000092997.1, ENSRNOT00000108981.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37800339..37823706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249328.4 → XP_006249390.1  N-lysine methyltransferase KMT5A isoform X3

      UniProtKB/TrEMBL
      A0A8J8XFN9
      Conserved Domains (1) summary
      smart00317
      Location:222 → 339
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    2. XM_063271679.1 → XP_063127749.1  N-lysine methyltransferase KMT5A isoform X7

    3. XM_017598458.3 → XP_017453947.1  N-lysine methyltransferase KMT5A isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZQS7, A6J0Z8
      Related
      ENSRNOP00000080894.1
      Conserved Domains (1) summary
      cd10528
      Location:143 → 282
      SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

    4. XM_039089771.2 → XP_038945699.1  N-lysine methyltransferase KMT5A isoform X4

      UniProtKB/TrEMBL
      A0A8J8XFN9, D3ZEB9, F7J138
      Related
      ENSRNOP00000062763.3
      Conserved Domains (1) summary
      cd10528
      Location:197 → 336
      SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

    5. XM_063271675.1 → XP_063127745.1  N-lysine methyltransferase KMT5A isoform X1

    6. XM_039089773.2 → XP_038945701.1  N-lysine methyltransferase KMT5A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZY89, A0A8J8XFN9
      Conserved Domains (1) summary
      cd10528
      Location:192 → 331
      SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

    7. XM_063271677.1 → XP_063127747.1  N-lysine methyltransferase KMT5A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZY89

    8. XM_063271676.1 → XP_063127746.1  N-lysine methyltransferase KMT5A isoform X2

    9. XM_006249330.4 → XP_006249392.1  N-lysine methyltransferase KMT5A isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZQS7, A6J0Z8
      Conserved Domains (1) summary
      cd10528
      Location:143 → 282
      SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

    RNA

    1. XR_010056419.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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