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    Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 67955, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Sugt1provided by MGI
    Official Full Name
    SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1915205
    See related
    Ensembl:ENSMUSG00000022024 AllianceGenome:MGI:1915205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGT1; 2410174K12Rik
    Summary
    Predicted to be involved in protein stabilization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; eye; nervous system; reproductive system; and respiratory system. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.7), placenta adult (RPKM 20.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D3; 14 42.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79825100..79868237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79587660..79630797)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon TTC) Neighboring gene claspin homolog pseudogene Neighboring gene E74 like ETS transcription factor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:79915269-79915570 Neighboring gene STARR-positive B cell enhancer ABC_E9411 Neighboring gene STARR-positive B cell enhancer ABC_E9903 Neighboring gene STARR-seq mESC enhancer starr_37267 Neighboring gene STARR-positive B cell enhancer ABC_E2430 Neighboring gene chondromodulin Neighboring gene predicted gene, 41218

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The oncogenic role of the cochaperone Sgt1. Ogi H, et al. Oncogenesis, 2015 May 18. PMID 25985210, Free PMC Article
    2. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. Sbroggiò M, et al. FEBS Lett, 2008 Jun 11. PMID 18474241
    3. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Li Y, et al. Nat Commun, 2020 Jun 1. PMID 32483152, Free PMC Article
    4. Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. Liu XS, et al. Mol Cell Biol, 2012 Oct. PMID 22869522, Free PMC Article
    5. Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1. Hong TJ, et al. J Biol Chem, 2013 Jan 4. PMID 23184943, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis.
      Title: miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis.
    2. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly.
      Title: Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly.
    3. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
      Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lncRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle satellite cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle satellite cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein SGT1 homolog
    Names
    suppressor of G2 allele of SKP1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026474.6 → NP_080750.1  protein SGT1 homolog

      See identical proteins and their annotated locations for NP_080750.1

      Status: VALIDATED

      Source sequence(s)
      AC129216, AK082328, AK141416
      Consensus CDS
      CCDS36988.1
      UniProtKB/Swiss-Prot
      Q3UF88, Q9CRE7, Q9CX34, Q9D8M6
      Related
      ENSMUSP00000052942.9, ENSMUST00000054908.10
      Conserved Domains (6) summary
      cd06489
      Location:146 → 229
      p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
      smart00028
      Location:45 → 78
      TPR; Tetratricopeptide repeats
      PLN03088
      Location:21 → 336
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:44 → 74
      TPR; TPR repeat [structural motif]
      cl22853
      Location:38 → 107
      Motor_domain; Myosin and Kinesin motor domain
      pfam05002
      Location:256 → 336
      SGS; SGS domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      79825100..79868237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CX34.3 GenPept UniProtKB/Swiss-Prot:Q9CX34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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