Rbm22 RNA binding motif protein 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm22provided by MGI
Official Full Name: RNA binding motif protein 22provided by MGI
Primary source: MGI:MGI:1914060
See related: Ensembl:ENSMUSG00000024604 AllianceGenome:MGI:1914060
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8430430L24Rik
Summary: Predicted to enable U6 snRNA binding activity; calcium-dependent protein binding activity; and pre-mRNA binding activity. Predicted to be involved in several processes, including mRNA cis splicing, via spliceosome; positive regulation of RNA splicing; and positive regulation of nucleocytoplasmic transport. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Prp19 complex; U2-type catalytic step 1 spliceosome; and U2-type catalytic step 2 spliceosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 18.7), CNS E14 (RPKM 17.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D3; 18 34.36 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (60693858..60705801)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (60560786..60572729)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rbm22 (e-PCR), detects polymorphism
- UniSTS:479229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U6 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in mRNA cis splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 1 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-mRNA-splicing factor RBM22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025776.2 → NP_080052.1 pre-mRNA-splicing factor RBM22

See identical proteins and their annotated locations for NP_080052.1

Status: PROVISIONAL

Source sequence(s)

AK168919

Consensus CDS

CCDS29272.1

UniProtKB/Swiss-Prot

Q3TJB0, Q8BHS3, Q9CXA0

Related

ENSMUSP00000025506.7, ENSMUST00000025506.7

Conserved Domains (2) summary

smart00356
Location:159 → 185

ZnF_C3H1; zinc finger

cd12224
Location:231 → 304

RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins