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    Cox20 cytochrome c oxidase assembly protein 20 [ Mus musculus (house mouse) ]

    Gene ID: 66359, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cox20provided by MGI
    Official Full Name
    cytochrome c oxidase assembly protein 20provided by MGI
    Primary source
    MGI:MGI:1913609
    See related
    Ensembl:ENSMUSG00000026500 AllianceGenome:MGI:1913609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam36a; 2310005N03Rik
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX20 (cytochrome c oxidase assembly factor COX20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 18.9), CNS E11.5 (RPKM 17.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H4; 1 83.16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178146379..178150258)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178318095..178322693)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03142 Neighboring gene predicted gene, 46174 Neighboring gene STARR-seq mESC enhancer starr_03146 Neighboring gene RIKEN cDNA B230369F24 gene Neighboring gene STARR-seq mESC enhancer starr_03147 Neighboring gene STARR-seq mESC enhancer starr_03148 Neighboring gene STARR-seq mESC enhancer starr_03149 Neighboring gene heterogeneous nuclear ribonucleoprotein U Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:180299062-180299171 Neighboring gene STARR-positive B cell enhancer ABC_E10066 Neighboring gene predicted gene, 24919 Neighboring gene STARR-seq mESC enhancer starr_03153 Neighboring gene EF-hand calcium binding domain 2 Neighboring gene predicted gene, 53484

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly protein COX20, mitochondrial
    Names
    COX20 Cox2 chaperone
    cytochrome c oxidase protein 20 homolog
    family with sequence similarity 36, member A
    protein FAM36A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025511.2 → NP_079787.1  cytochrome c oxidase assembly protein COX20, mitochondrial

      See identical proteins and their annotated locations for NP_079787.1

      Status: VALIDATED

      Source sequence(s)
      AK009178, BY779933
      Consensus CDS
      CCDS15556.1
      UniProtKB/Swiss-Prot
      Q8BT52, Q9D7J4
      Related
      ENSMUSP00000027781.7, ENSMUST00000027781.7
      Conserved Domains (1) summary
      pfam12597
      Location:13 → 97
      DUF3767; Protein of unknown function (DUF3767)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      178146379..178150258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321962.3 → XP_017177451.1  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X2

    2. XM_036152821.1 → XP_036008714.1  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam12597
      Location:36 → 118
      DUF3767; Protein of unknown function (DUF3767)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7J4.1 GenPept UniProtKB/Swiss-Prot:Q9D7J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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