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    Snupn snurportin 1 [ Mus musculus (house mouse) ]

    Gene ID: 66069, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snupnprovided by MGI
    Official Full Name
    snurportin 1provided by MGI
    Primary source
    MGI:MGI:1913319
    See related
    Ensembl:ENSMUSG00000055334 AllianceGenome:MGI:1913319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnut1; Snupn1; 0610031A09Rik
    Summary
    Predicted to enable RNA binding activity and nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus and snRNA import into nucleus. Predicted to be located in cytoplasm and nucleus. Is expressed in embryo. Orthologous to human SNUPN (snurportin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.0), testis adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snupn in Genome Data Viewer
    Location:
    9 B; 9 30.57 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56855158..56893545)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56949419..56986261)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1386 Neighboring gene predicted gene, 19936 Neighboring gene STARR-positive B cell enhancer ABC_E3831 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56798396-56798654 Neighboring gene IMP3, U3 small nucleolar ribonucleoprotein Neighboring gene STARR-seq mESC enhancer starr_24215 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658 Neighboring gene STARR-positive B cell enhancer ABC_E5069 Neighboring gene STARR-seq mESC enhancer starr_24217 Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9329 Neighboring gene STARR-positive B cell enhancer ABC_E711 Neighboring gene transcriptional regulator, SIN3A (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. Huber J, et al. EMBO J, 1998 Jul 15. PMID 9670026, Free PMC Article
    2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    3. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    snurportin-1
    Names
    RNA, U transporter 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178374.4 → NP_848461.1  snurportin-1

      See identical proteins and their annotated locations for NP_848461.1

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC132406
      Consensus CDS
      CCDS23214.1
      UniProtKB/Swiss-Prot
      Q80W37
      Related
      ENSMUSP00000067200.5, ENSMUST00000068856.5
      Conserved Domains (2) summary
      cd09232
      Location:98 → 282
      Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1
      pfam11538
      Location:25 → 64
      Snurportin1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56855158..56893545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511336.3 → XP_006511399.1  snurportin-1 isoform X2

      Conserved Domains (1) summary
      cd09232
      Location:26 → 210
      Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1

    2. XM_011242784.4 → XP_011241086.1  snurportin-1 isoform X1

      See identical proteins and their annotated locations for XP_011241086.1

      UniProtKB/Swiss-Prot
      Q80W37
      Conserved Domains (2) summary
      cd09232
      Location:98 → 282
      Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1
      pfam11538
      Location:25 → 64
      Snurportin1

    3. XM_030244488.1 → XP_030100348.1  snurportin-1 isoform X3

      Conserved Domains (1) summary
      cd09232
      Location:11 → 131
      Snurportin-1_C; C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1

    RNA

    1. XR_003947964.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W37.1 GenPept UniProtKB/Swiss-Prot:Q80W37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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