Fads2 fatty acid desaturase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fads2provided by MGI
Official Full Name: fatty acid desaturase 2provided by MGI
Primary source: MGI:MGI:1930079
See related: Ensembl:ENSMUSG00000024665 AllianceGenome:MGI:1930079
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fads2a; Fadsd2; 2900042M13Rik
Summary: Enables stearoyl-CoA 9-desaturase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in membrane. Is expressed in several structures, including adrenal gland; genitourinary system; nervous system; and retina. Orthologous to human FADS2 (fatty acid desaturase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 555.1), liver adult (RPKM 281.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.36 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10040129..10078867, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10062765..10101503, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Delta-6 desaturase reduces fatty acid re-esterification in 3T3-L1 adipocytes independent of changes in n3-PUFA cellular content.
Title: Inhibition of Δ-6 desaturase reduces fatty acid re-esterification in 3T3-L1 adipocytes independent of changes in n3-PUFA cellular content.
High fat / high cholesterol diet does not provoke atherosclerosis in the omega3-and omega6-polyunsaturated fatty acid synthesis-inactivated Delta6-fatty acid desaturase-deficient mouse.
Title: High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis-inactivated Δ6-fatty acid desaturase-deficient mouse.
Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice.
Title: Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice.
Dietary omega3-and omega6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice.
Title: Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice.
Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance.
Title: Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance.
Describe a novel SNP in the Fads2 gene encoding Delta6-desaturase, a key enzyme in the metabolic pathways of polyunsaturated fatty acids. The allele frequencies of Fads2 were significantly different in two lines of mice divergently selected for either high or low basal metabolic rate.
Title: A novel polymorphism in the fatty acid desaturase 2 gene (Fads2): A possible role in the basal metabolic rate.
Data (including data from studies using knockout mice) suggest that increased dietary intake of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) differentially affects activity of D5D/Fads1 and D6D/Fads2 in specific tissues.
Title: Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice.
In comparison, Fads2-/- and WT mice fed AD showed minimal differences in n-6 PUFA content in serum and WAT, despite having significantly more AA than CD-fed mice. No differences in gene expression for common inflammatory adipokines (e.g. Mcp-1, Ccl5, Tnfalpha) or key regulators of eicosanoid production (e.g. Cox-2, Alox-12, Alox-15) were detected in WAT between any of the diet and genotype groups
Title: Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets.
In this study, an obvious hepatic lipid accumulation was observed in essential fatty acid deficiency (EFAD) mice treated with a FADS2 inhibitor. FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma.
Title: FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion.
Data (including data from studies using knockout mice) suggest that immunomodulatory effects of dietary omega-6 vs. omega-3 fatty acids are due, in part, to interconversion of the various unsaturated fatty acids consumed/administered; thus, delta-6 desaturase plays role in immunomodulatory effects of dietary unsaturated fatty acids.
Title: The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19Mit42 (e-PCR), detects polymorphism
- UniSTS:128383

Fads2 (e-PCR), detects polymorphism
- UniSTS:546766

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables linoleoyl-CoA desaturase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolite production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: acyl-CoA 6-desaturase

Names: D6D; delta(6) desaturase; delta(6) fatty acid desaturase

NP_062673.1

EC 1.14.19.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019699.2 → NP_062673.1 acyl-CoA 6-desaturase

See identical proteins and their annotated locations for NP_062673.1

Status: VALIDATED

Source sequence(s)

AC135670

Consensus CDS

CCDS29571.1

UniProtKB/Swiss-Prot

Q9Z0R9

UniProtKB/TrEMBL

F2WWK6

Related

ENSMUSP00000025567.8, ENSMUST00000025567.9

Conserved Domains (3) summary

PLN03199
Location:1 → 439

PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional

cd03506
Location:162 → 412

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00173
Location:20 → 94

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain