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    TDRD1 tudor domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 56165, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TDRD1provided by HGNC
    Official Full Name
    tudor domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:11712
    See related
    Ensembl:ENSG00000095627 MIM:605796; AllianceGenome:HGNC:11712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT41.1
    Summary
    This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]
    Expression
    Biased expression in testis (RPKM 8.5) and prostate (RPKM 0.6) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q25.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114174874..114232666)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115068498..115126291)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (115939046..115992425)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene UBE2V1 pseudogene 5 Neighboring gene coiled-coil domain containing 186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:115933644-115934172 Neighboring gene microRNA 2110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115998924-115999632 Neighboring gene MPRA-validated peak1096 silencer Neighboring gene aurora kinase A pseudogene 2 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene MPRA-validated peak1097 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116036689-116037189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116037297-116037798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116045355-116045966 Neighboring gene actin filament associated protein 1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2843 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116079781-116080980 Neighboring gene uncharacterized LOC105378494

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery. Kim H, et al. Oncogene, 2023 Jun. PMID 37041411
    2. The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker. Xiao L, et al. Prostate, 2016 Oct. PMID 27272765
    3. Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese. Zhu XB, et al. J Assist Reprod Genet, 2016 Aug. PMID 27233649, Free PMC Article
    4. Mutational alterations of TDRD 1, 4 and 9 genes in colorectal cancers. Mo HY, et al. Pathol Oncol Res, 2020 Jul. PMID 32036563
    5. ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer. Kacprzyk LA, et al. PLoS One, 2013. PMID 23555854, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery.
      Title: The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery.
    2. Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy.
      Title: Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy.
    3. Mutational alterations of TDRD 1, 4 and 9 genes in colorectal cancers.
      Title: Mutational alterations of TDRD 1, 4 and 9 genes in colorectal cancers.
    4. Here we evaluate gene and protein expression levels of four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular biopsy samples obtained from men with obstructive azoospermia (OA, n = 29), as controls, and various types of non-obstructive azoospermia containing hypospermatogenesis (HP, 28), maturation arrest (MA, n = 30), and Sertoli cell-only syndrome (SCOS, n = 32) as cases.
      Title: Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.
    5. TDRD1 protein is expressed in the majority of human prostate tumors, but not in normal prostate tissue.
      Title: The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.
    6. the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in the risk of spermatogenic impairment in a Han Chinese population
      Title: Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese.
    7. ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer.
      Title: ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer.
    8. TDRD1 is the first identified upregulated direct ERG target gene that is strongly associated with ERG overexpression in primary prostate cancer
      Title: Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer.
    9. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21082

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in siRNA-mediated retrotransposon silencing by heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatoid body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in pi-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tudor domain-containing protein 1
    Names
    cancer/testis antigen 41.1
    testicular tissue protein Li 193

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365891.2 → NP_001352820.1  tudor domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022023, BX648664
      Conserved Domains (2) summary
      pfam00567
      Location:712 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger

    2. NM_001385363.1 → NP_001372292.1  tudor domain-containing protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS7588.1
      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    3. NM_001385364.2 → NP_001372293.1  tudor domain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91352.1
      UniProtKB/Swiss-Prot
      A6NEN3, A6NMN2, B3KVI4, B4E2L5, D3DRC2, Q4G0Y8, Q6P518, Q9BXT4, Q9H7B3
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    4. NM_001385365.1 → NP_001372294.1  tudor domain-containing protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    5. NM_001385366.1 → NP_001372295.1  tudor domain-containing protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:658 → 775
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:887 → 1002
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cl02573
      Location:517 → 553
      Tudor_SF; Tudor domain superfamily

    6. NM_001385367.1 → NP_001372296.1  tudor domain-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91353.1
      UniProtKB/TrEMBL
      H9KV63
      Related
      ENSP00000358288.1, ENST00000369282.5
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    7. NM_001385368.1 → NP_001372297.1  tudor domain-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91354.1
      UniProtKB/TrEMBL
      H9KV62
      Related
      ENSP00000358286.1, ENST00000369280.1
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    8. NM_001385369.1 → NP_001372298.1  tudor domain-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91354.1
      UniProtKB/TrEMBL
      H9KV62
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    9. NM_001385370.1 → NP_001372299.1  tudor domain-containing protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:658 → 726
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:830 → 945
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cl02573
      Location:517 → 553
      Tudor_SF; Tudor domain superfamily

    10. NM_001385371.1 → NP_001372300.1  tudor domain-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:667 → 784
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20409
      Location:469 → 550
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:896 → 1010
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cl02573
      Location:268 → 348
      Tudor_SF; Tudor domain superfamily

    11. NM_001385372.1 → NP_001372301.1  tudor domain-containing protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    12. NM_001395205.1 → NP_001382134.1  tudor domain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91352.1
      UniProtKB/Swiss-Prot
      A6NEN3, A6NMN2, B3KVI4, B4E2L5, D3DRC2, Q4G0Y8, Q6P518, Q9BXT4, Q9H7B3
      Related
      ENSP00000511878.1, ENST00000695399.1
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    13. NM_198795.2 → NP_942090.1  tudor domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_942090.1

      Status: REVIEWED

      Source sequence(s)
      AC022023, AK122916, BC035010, BQ882979, BX648664, CB136029
      Consensus CDS
      CCDS7588.1
      UniProtKB/TrEMBL
      A0A140VJW6
      Related
      ENSP00000251864.2, ENST00000251864.7
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114174874..114232666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539962.2 → XP_011538264.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538264.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    2. XM_011539964.3 → XP_011538266.1  tudor domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      cd04508
      Location:709 → 756
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:655 → 775
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger

    3. XM_047425489.1 → XP_047281445.1  tudor domain-containing protein 1 isoform X6

    4. XM_017016414.3 → XP_016871903.1  tudor domain-containing protein 1 isoform X2

    5. XM_047425488.1 → XP_047281444.1  tudor domain-containing protein 1 isoform X5

    6. XM_047425487.1 → XP_047281443.1  tudor domain-containing protein 1 isoform X4

    7. XM_047425491.1 → XP_047281447.1  tudor domain-containing protein 1 isoform X7

    8. XM_047425486.1 → XP_047281442.1  tudor domain-containing protein 1 isoform X3

    9. XM_047425490.1 → XP_047281446.1  tudor domain-containing protein 1 isoform X6

    10. XM_047425492.1 → XP_047281448.1  tudor domain-containing protein 1 isoform X7

    11. XM_011539959.3 → XP_011538261.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538261.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    12. XM_011539960.3 → XP_011538262.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538262.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    13. XM_011539961.3 → XP_011538263.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538263.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715 → 832
      TUDOR; Tudor domain
      pfam01753
      Location:170 → 206
      zf-MYND; MYND finger
      cd20408
      Location:268 → 396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517 → 598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:944 → 1059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115068498..115126291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366308.1 → XP_054222283.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6

    2. XM_054366310.1 → XP_054222285.1  tudor domain-containing protein 1 isoform X3

    3. XM_054366314.1 → XP_054222289.1  tudor domain-containing protein 1 isoform X6

    4. XM_054366309.1 → XP_054222284.1  tudor domain-containing protein 1 isoform X2

    5. XM_054366313.1 → XP_054222288.1  tudor domain-containing protein 1 isoform X5

    6. XM_054366312.1 → XP_054222287.1  tudor domain-containing protein 1 isoform X4

    7. XM_054366316.1 → XP_054222291.1  tudor domain-containing protein 1 isoform X7

    8. XM_054366311.1 → XP_054222286.1  tudor domain-containing protein 1 isoform X3

    9. XM_054366315.1 → XP_054222290.1  tudor domain-containing protein 1 isoform X6

    10. XM_054366317.1 → XP_054222292.1  tudor domain-containing protein 1 isoform X7

    11. XM_054366305.1 → XP_054222280.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6

    12. XM_054366306.1 → XP_054222281.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6

    13. XM_054366307.1 → XP_054222282.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031278.1: Suppressed sequence

      Description
      NM_031278.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXT4.2 GenPept UniProtKB/Swiss-Prot:Q9BXT4

    Gene LinkOut

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