Ramp1 receptor (calcitonin) activity modifying protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ramp1provided by MGI
Official Full Name: receptor (calcitonin) activity modifying protein 1provided by MGI
Primary source: MGI:MGI:1858418
See related: Ensembl:ENSMUSG00000034353 AllianceGenome:MGI:1858418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130218E19Rik
Summary: Enables coreceptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in extracellular space. Predicted to be part of CGRP receptor complex and amylin receptor complex 1. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and reproductive system. Orthologous to human RAMP1 (receptor activity modifying protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 23.9), colon adult (RPKM 15.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.08 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91107544..91152918)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91179822..91225196)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
Title: TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Galphai3-PKA-CREB-YAP axis.
Title: Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Gαi3-PKA-CREB-YAP axis.
RAMP1 and RAMP3 Differentially Control Amylin's Effects on Food Intake, Glucose and Energy Balance in Male and Female Mice.
Title: RAMP1 and RAMP3 Differentially Control Amylin's Effects on Food Intake, Glucose and Energy Balance in Male and Female Mice.
Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.
Title: Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.
The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.
Title: The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.
RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis.
Title: RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis.
Data suggest the molecular mechanisms of receptor activity-modifying protein 1 (RAMP1) in angiogenesis.
Title: The influence of receptor activity-modifying protein-1 overexpression on angiogenesis in mouse brain capillary endothelial cells.
CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
Title: CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
RAMP1 promotes CGRP-induced osteogenic differentiation of bone marrow mesenchymal stem cells via regulation of the Hippo/Yap pathway.
Title: Receptor activity-modifying protein 1 regulates the phenotypic expression of BMSCs via the Hippo/Yap pathway.
Mice lacking RAMP1 showed increased inflammation, tissue edema, and pancreas injury particularly in the early phase of acute pancreatitis
Title: The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amylin receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide binding	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables coreceptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcitonin gene-related peptide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CGRP receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor activity-modifying protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168392.1 → NP_001161864.1 receptor activity-modifying protein 1 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC102874, BY707433, CB522711

Consensus CDS

CCDS48321.1

UniProtKB/TrEMBL

A0A087WPC6

Related

ENSMUSP00000139720.2, ENSMUST00000188475.7

Conserved Domains (1) summary

pfam04901
Location:37 → 63

RAMP; Receptor activity modifying family
NM_016894.3 → NP_058590.1 receptor activity-modifying protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_058590.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC102874, AK165238, BY733497

Consensus CDS

CCDS15158.1

UniProtKB/Swiss-Prot

Q9WTJ5

UniProtKB/TrEMBL

Q3TNJ3

Related

ENSMUSP00000095253.5, ENSMUST00000097648.6

Conserved Domains (1) summary

pfam04901
Location:38 → 145

RAMP; Receptor activity modifying family
NM_178401.3 → NP_848488.2 receptor activity-modifying protein 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

BY733497, CB522711

Consensus CDS

CCDS78648.1

UniProtKB/TrEMBL

E9Q915

Related

ENSMUSP00000128679.3, ENSMUST00000165855.8

Conserved Domains (1) summary

pfam04901
Location:37 → 63

RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

91107544..91152918

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321671.1 → XP_017177160.1 receptor activity-modifying protein 1 isoform X1

Conserved Domains (1) summary

pfam04901
Location:15 → 123

RAMP; Receptor activity modifying family