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    MCL1 MCL1 apoptosis regulator, BCL2 family member [ Pan troglodytes (chimpanzee) ]

    Gene ID: 457274, updated on 29-Mar-2024

    Summary

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    Official Symbol
    MCL1provided by VGNC
    Official Full Name
    MCL1 apoptosis regulator, BCL2 family memberprovided by VGNC
    Primary source
    VGNC:VGNC:1312
    Locus tag
    CK820_G0046961
    See related
    Ensembl:ENSPTRG00000001260
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (98641316..98648014)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (132701721..132707098, complement)

    Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene eukaryotic translation initiation factor 3 subunit F-like Neighboring gene ADAMTS like 4 Neighboring gene uncharacterized LOC104002583 Neighboring gene uncharacterized LOC104002588

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    induced myeloid leukemia cell differentiation protein Mcl-1
    Names
    BCL2 family apoptosis regulator
    MCL1, BCL2 family apoptosis regulator
    myeloid cell leukemia 1
    myeloid cell leukemia sequence 1 (BCL2-related)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      98641316..98648014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016926498.3 → XP_016781987.1  induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8JJ40, A0A6D2X745, H2PZX1, K7AVP2, K7D0E2
      Related
      ENSPTRP00000002137.5
      Conserved Domains (2) summary
      cd06845
      Location:175 → 318
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      cl00232
      Location:30 → 122
      Ribosomal_L19e; Ribosomal protein L19e. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment. ...

    2. XM_016926502.3 → XP_016781991.1  induced myeloid leukemia cell differentiation protein Mcl-1 isoform X2

      UniProtKB/TrEMBL
      A0A2J8JJ42, A0A6D2W9C2, K7ADG8, K7DE58
      Related
      ENSPTRP00000080232.1
      Conserved Domains (1) summary
      cl02575
      Location:175 → 230
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    Nucleotide Protein
    Heading Accession and Version

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