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    Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406165, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Agpat1provided by RGD
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 1provided by RGD
    Primary source
    RGD:1303287
    See related
    Ensembl:ENSRNOG00000000437 AllianceGenome:RGD:1303287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process and positive regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 171.6), Testes (RPKM 109.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4140565..4149531, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4135955..4144880, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4369399..4378272)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase like Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene ring finger protein 5 Neighboring gene advanced glycosylation end product-specific receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. Aguado B, et al. J Biol Chem, 1998 Feb 13. PMID 9461603
    2. cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Kume K, et al. Biochem Biophys Res Commun, 1997 Aug 28. PMID 9299423
    3. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. West J, et al. DNA Cell Biol, 1997 Jun. PMID 9212163
    4. Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. Agarwal AK, et al. J Biol Chem, 2011 Oct 28. PMID 21873652, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94573

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Names
    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
    NP_997623.1
    XP_006256036.1
    XP_006256037.1
    XP_038954860.1
    XP_063135419.1
    XP_063135420.1
    XP_063135422.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212458.1 → NP_997623.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

      See identical proteins and their annotated locations for NP_997623.1

      Status: VALIDATED

      Source sequence(s)
      BX883044
      UniProtKB/TrEMBL
      A6KTH1, Q5U2V3, Q6MG85
      Conserved Domains (1) summary
      cd07989
      Location:66 → 252
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4140565..4149531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279352.1 → XP_063135422.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

      UniProtKB/TrEMBL
      F7EQT9

    2. XM_006255974.3 → XP_006256036.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

      See identical proteins and their annotated locations for XP_006256036.1

      UniProtKB/TrEMBL
      A6KTH1, Q5U2V3, Q6MG85
      Conserved Domains (1) summary
      cd07989
      Location:66 → 252
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    3. XM_063279349.1 → XP_063135419.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

      UniProtKB/TrEMBL
      F7EQT9

    4. XM_039098932.2 → XP_038954860.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

      UniProtKB/TrEMBL
      A6KTH1, Q5U2V3, Q6MG85
      Conserved Domains (1) summary
      cd07989
      Location:66 → 252
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    5. XM_063279350.1 → XP_063135420.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

      UniProtKB/TrEMBL
      F7EQT9

    6. XM_006255975.3 → XP_006256037.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

      See identical proteins and their annotated locations for XP_006256037.1

      UniProtKB/TrEMBL
      A6KTH1, Q5U2V3, Q6MG85
      Conserved Domains (1) summary
      cd07989
      Location:66 → 252
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    Nucleotide Protein Strain
    Heading Accession and Version

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