Uba1 ubiquitin-like modifier activating enzyme 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uba1provided by RGD
Official Full Name: ubiquitin-like modifier activating enzyme 1provided by RGD
Primary source: RGD:1359327
See related: Ensembl:ENSRNOG00000019164 AllianceGenome:RGD:1359327
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ube1x
Summary: Predicted to enable ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle; desmosome; and heterochromatin. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 374.7), Adrenal (RPKM 358.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (4062216..4084192, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (1508700..1530677, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (1723135..1745147, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBA1 inhibition effectively suppresses neointimal thickening through its anti-proliferative and anti-inflammatory effects in carotid artery injury.
Title: The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis.
E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage
Title: Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA989744 (e-PCR)
- UniSTS:166176

Ube1x (e-PCR), detects polymorphism
- UniSTS:144720

UniSTS:256410 (e-PCR)
- UniSTS:256410

Ube1x (e-PCR), detects polymorphism
- UniSTS:256410

RH129666 (e-PCR)
- UniSTS:212963

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin activating enzyme activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
part_of heterochromatin	IEA Inferred from Electronic Annotation more info
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme 1

Names: ubiquitin-activating enzyme E1, Chr X

NP_001014102.1

EC 6.2.1.45

XP_006256674.1

EC 6.2.1.45

XP_006256675.2

EC 6.2.1.45

XP_063136075.1

EC 6.2.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014080.1 → NP_001014102.1 ubiquitin-like modifier-activating enzyme 1

See identical proteins and their annotated locations for NP_001014102.1

Status: PROVISIONAL

Source sequence(s)

BC085791

UniProtKB/Swiss-Prot

Q5U300

UniProtKB/TrEMBL

A0A8L2QII5

Conserved Domains (1) summary

TIGR01408
Location:49 → 1055

Ube1; ubiquitin-activating enzyme E1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

4062216..4084192 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256613.4 → XP_006256675.2 ubiquitin-like modifier-activating enzyme 1 isoform X1

UniProtKB/Swiss-Prot

Q5U300

UniProtKB/TrEMBL

A0A8L2QII5

Conserved Domains (1) summary

TIGR01408
Location:49 → 1055

Ube1; ubiquitin-activating enzyme E1
XM_006256612.5 → XP_006256674.1 ubiquitin-like modifier-activating enzyme 1 isoform X1

See identical proteins and their annotated locations for XP_006256674.1

UniProtKB/Swiss-Prot

Q5U300

UniProtKB/TrEMBL

A0A8L2QII5

Related

ENSRNOP00000084488.1

Conserved Domains (1) summary

TIGR01408
Location:49 → 1055

Ube1; ubiquitin-activating enzyme E1
XM_063280005.1 → XP_063136075.1 ubiquitin-like modifier-activating enzyme 1 isoform X1

UniProtKB/Swiss-Prot

Q5U300