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    Mcmbp minichromosome maintenance complex binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309009, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mcmbpprovided by RGD
    Official Full Name
    minichromosome maintenance complex binding proteinprovided by RGD
    Primary source
    RGD:1306730
    See related
    Ensembl:ENSRNOG00000020394 AllianceGenome:RGD:1306730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCM-BP; RGD1306730
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA-dependent DNA replication and sister chromatid cohesion. Predicted to be located in cell junction; cytosol; and nucleoplasm. Orthologous to human MCMBP (minichromosome maintenance complex binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 146.9), Spleen (RPKM 134.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q37
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192702383..192747381, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (183270598..183316975, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (200118226..200163106, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BAG cochaperone 3 Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene SEC23 interacting protein Neighboring gene small nucleolar RNA U109

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. Nishiyama A, et al. Genes Dev, 2011 Jan 15. PMID 21196493, Free PMC Article
    2. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. Takahashi N, et al. PLoS Genet, 2010 Jan 15. PMID 20090939, Free PMC Article
    3. Identification and characterization of a novel component of the human minichromosome maintenance complex. Sakwe AM, et al. Mol Cell Biol, 2007 Apr. PMID 17296731, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125204

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mini-chromosome maintenance complex-binding protein
    Names
    MCM-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039608.2 → NP_001034697.2  mini-chromosome maintenance complex-binding protein

      See identical proteins and their annotated locations for NP_001034697.2

      Status: VALIDATED

      Source sequence(s)
      BC160884
      UniProtKB/Swiss-Prot
      B1H268
      UniProtKB/TrEMBL
      A0A8I5ZSQ3
      Related
      ENSRNOP00000027644.5, ENSRNOT00000027644.6
      Conserved Domains (1) summary
      pfam09739
      Location:36 → 628
      MCM_bind; Mini-chromosome maintenance replisome factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192702383..192747381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078498.2 → XP_038934426.1  mini-chromosome maintenance complex-binding protein isoform X1

      Conserved Domains (1) summary
      pfam09739
      Location:1 → 344
      MCM_bind; Mini-chromosome maintenance replisome factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1H268.1 GenPept UniProtKB/Swiss-Prot:B1H268

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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