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    LPAR4 lysophosphatidic acid receptor 4 [ Homo sapiens (human) ]

    Gene ID: 2846, updated on 11-Apr-2024

    Summary

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    Official Symbol
    LPAR4provided by HGNC
    Official Full Name
    lysophosphatidic acid receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:4478
    See related
    Ensembl:ENSG00000147145 MIM:300086; AllianceGenome:HGNC:4478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPA4; P2Y9; GPR23; P2RY9; P2Y5-LIKE
    Summary
    This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    Location:
    Xq21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78747720..78758714)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (77184471..77195526)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78003217..78014211)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985670 Neighboring gene retrotransposon Gag like 3 Neighboring gene phosphoribosyl pyrophosphate amidotransferase pseudogene 2 Neighboring gene ribosomal protein L7 pseudogene 54 Neighboring gene microRNA 4328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation. Wu C, et al. Nat Cell Biol, 2023 Feb. PMID 36646789, Free PMC Article
    2. Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells. Matayoshi S, et al. Int J Oncol, 2013 May. PMID 23467751, Free PMC Article
    3. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. Noguchi K, et al. J Biol Chem, 2003 Jul 11. PMID 12724320
    4. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. Janssens R, et al. Biochem Biophys Res Commun, 1997 Jul 9. PMID 9223435
    5. LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts. Kowalczyk-Zieba I, et al. Reprod Sci, 2019 Jan. PMID 29621954

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
      Title: Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
    2. Potential genetic biomarkers predict adverse pregnancy outcome during early and mid-pregnancy in women with systemic lupus erythematosus.
      Title: Potential genetic biomarkers predict adverse pregnancy outcome during early and mid-pregnancy in women with systemic lupus erythematosus.
    3. Study shows that due to the high LPAR2 and LPAR4 transcript and protein expression in endometriotic ovarian cysts and positive correlations of both these receptors with the PR-B and ERbeta, respectively, those receptors seem to be the most promising predictors of the endometriotic cysts.
      Title: LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts.
    4. Mutation in LPAR4 gene is associated with papillary thyroid carcinoma.
      Title: Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations.
    5. These results suggest that the diverse roles of LPA4, LPA5 and LPA6 are involved in the activation of tumor progression in pancreatic cancer cells.
      Title: Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.
    6. Our data suggest that LPA4 signaling potentially modulates malignant behavior of SQ-20B cells.
      Title: Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells.
    7. LPA4 gene mutation may play some role in the pathogenesis of colon cancer.
      Title: Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.
    8. LPA4 and LPA5 receptors induce osteoblastic differentiation of human mesenchymal stem cells
      Title: LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.
    9. Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
      Title: Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.
    10. identified as the fourth lysophosphatidic acid (LPA) receptor; shares only 20-24% amino acid identities with Edg-2/LPA1, Edg-4/LPA2, and Edg-7/LPA3, and phylogenetic analysis also shows that p2y9/GPR23 is far distant from the Edg family
      Title: Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysophosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 4
    Names
    G-protein coupled receptor 23
    LPA receptor 4
    LPA-4
    P2Y purinoceptor 9
    P2Y5-like receptor
    purinergic receptor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013242.1 RefSeqGene

      Range
      5012..16006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278000.3 → NP_001264929.1  lysophosphatidic acid receptor 4

      See identical proteins and their annotated locations for NP_001264929.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL590083
      Consensus CDS
      CCDS14441.1
      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
      Related
      ENSP00000478261.1, ENST00000614823.5
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51 → 165
      7tm_4; Olfactory receptor

    2. NM_005296.3 → NP_005287.1  lysophosphatidic acid receptor 4

      See identical proteins and their annotated locations for NP_005287.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks alternate exons in the 5'UTR. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA424772, AK314134, AL590083, BM973092, BX100826, U90322
      Consensus CDS
      CCDS14441.1
      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
      Related
      ENSP00000408205.2, ENST00000435339.3
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51 → 165
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      78747720..78758714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442014.1 → XP_047297970.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    2. XM_047442015.1 → XP_047297971.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    3. XM_017029437.2 → XP_016884926.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51 → 165
      7tm_4; Olfactory receptor

    4. XM_047442013.1 → XP_047297969.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    5. XM_047442012.1 → XP_047297968.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    6. XM_047442011.1 → XP_047297967.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    7. XM_006724639.4 → XP_006724702.1  lysophosphatidic acid receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006724702.1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51 → 165
      7tm_4; Olfactory receptor

    8. XM_017029438.2 → XP_016884927.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51 → 165
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      77184471..77195526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326881.1 → XP_054182856.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    2. XM_054326883.1 → XP_054182858.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    3. XM_054326876.1 → XP_054182851.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    4. XM_054326880.1 → XP_054182855.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    5. XM_054326878.1 → XP_054182853.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    6. XM_054326877.1 → XP_054182852.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    7. XM_054326879.1 → XP_054182854.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

    8. XM_054326882.1 → XP_054182857.1  lysophosphatidic acid receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99677.1 GenPept UniProtKB/Swiss-Prot:Q99677

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