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    GNG10 G protein subunit gamma 10 [ Homo sapiens (human) ]

    Gene ID: 2790, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GNG10provided by HGNC
    Official Full Name
    G protein subunit gamma 10provided by HGNC
    Primary source
    HGNC:HGNC:4402
    See related
    Ensembl:ENSG00000242616 MIM:604389; AllianceGenome:HGNC:4402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in appendix (RPKM 57.2), adrenal (RPKM 51.1) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    9q31.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (111661605..111670226)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (123832965..123841586)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (114423885..114432506)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987116 Neighboring gene DNAJC25-GNG10 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28795 Neighboring gene FOXA motif-containing MPRA enhancer 227 Neighboring gene Sharpr-MPRA regulatory region 12797 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_105958 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28798 Neighboring gene Sharpr-MPRA regulatory region 3205 Neighboring gene shortage in chiasmata 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_105998 Neighboring gene uncharacterized LOC124902249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel somatic mutations in heterotrimeric G proteins in melanoma. Cárdenas-Navia LI, et al. Cancer Biol Ther, 2010 Jul 1. PMID 20424519, Free PMC Article
    2. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. Ray K, et al. J Biol Chem, 1995 Sep 15. PMID 7665596
    3. The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. Sun Z, et al. Cell Signal, 2012 Dec. PMID 22940628, Free PMC Article
    4. Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers. Mayeenuddin LH, et al. J Biol Chem, 2006 Jan 27. PMID 16301321
    5. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. Rosskopf D, et al. FEBS Lett, 2003 Jun 5. PMID 12782285

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GNG10 mutations are associated with melanoma.
      Title: Novel somatic mutations in heterotrimeric G proteins in melanoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
    Names
    guanine nucleotide binding protein (G protein), gamma 10
    guanine nucleotide binding protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017998.4 → NP_001017998.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

      See identical proteins and their annotated locations for NP_001017998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represent the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AW583403, BC107574, DB504443
      Consensus CDS
      CCDS35107.1
      UniProtKB/Swiss-Prot
      P50151, Q3B7K2, Q4VC27
      Related
      ENSP00000363411.3, ENST00000374293.5
      Conserved Domains (1) summary
      cd00068
      Location:7 → 63
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    2. NM_001198664.2 → NP_001185593.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

      See identical proteins and their annotated locations for NP_001185593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL135787, AW583403, BC010384, DB504443
      Consensus CDS
      CCDS35107.1
      UniProtKB/Swiss-Prot
      P50151, Q3B7K2, Q4VC27
      Conserved Domains (1) summary
      cd00068
      Location:7 → 63
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      111661605..111670226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      123832965..123841586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50151.1 GenPept UniProtKB/Swiss-Prot:P50151

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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