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    ARHGEF26 Rho guanine nucleotide exchange factor 26 [ Homo sapiens (human) ]

    Gene ID: 26084, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ARHGEF26provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 26provided by HGNC
    Primary source
    HGNC:HGNC:24490
    See related
    Ensembl:ENSG00000114790 MIM:617552; AllianceGenome:HGNC:24490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGEF; CSGEF; HMFN1864
    Summary
    This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q25.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (154121003..154257825)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (156892016..157032100)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (153838792..153975614)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene U8 small nucleolar RNA Neighboring gene ARHGEF26 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 42 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_65370 Neighboring gene uncharacterized LOC105374167 Neighboring gene MPRA-validated peak4869 silencer Neighboring gene DEAH-box helicase 36 Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, et al. PLoS Pathog, 2021 Jul. PMID 34242364, Free PMC Article
    2. SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide. Ensign SP, et al. Mol Cancer Res, 2016 Mar. PMID 26764186, Free PMC Article
    3. SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Wang H, et al. Oncol Rep, 2012 Oct. PMID 22824926
    4. Comparative proteomic analysis of advanced serous epithelial ovarian carcinoma: possible predictors of chemoresistant disease. Kim SW, et al. OMICS, 2011 May. PMID 21332407
    5. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Ellerbroek SM, et al. Mol Biol Cell, 2004 Jul. PMID 15133129, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
      Title: Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
    2. ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.
      Title: ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.
    3. SGEF plays a role in activating RhoG during invadopodia disassembly
      Title: A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.
    4. High SGEF expression is associated with lung adenocarcinoma.
      Title: SGEF is a potential prognostic and therapeutic target for lung adenocarcinoma.
    5. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.
      Title: Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
    6. yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF
      Title: Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.
    7. Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance.
      Title: SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.
    8. A novel function of SGEF that excludes GEF.
      Title: Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation.
    9. We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation
      Title: SGEF enhances EGFR stability through delayed EGFR trafficking from early to late endosomes.
    10. Data indicate that the Src homology 3 domain-containing GEF (SGEF) promotes fibroblast growth factor-inducible 14 (Fn14) proinvasive signaling in glioblastoma via TNF receptor-associated factor 2 (TRAF2).
      Title: The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp434D146

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 26
    Names
    Rho guanine nucleotide exchange factor (GEF) 26
    SH3 domain-containing guanine exchange factor
    Src homology 3 domain-containing guanine nucleotide exchange factor
    testicular tissue protein Li 171

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030405.1 RefSeqGene

      Range
      5388..141823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001251962.2 → NP_001238891.1  rho guanine nucleotide exchange factor 26 isoform 1

      See identical proteins and their annotated locations for NP_001238891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC018452, AK127282, AY552599
      Consensus CDS
      CCDS46938.1
      UniProtKB/Swiss-Prot
      B3KVP8, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q96DR7, Q9H9D7, Q9H9R2, Q9UFW5
      UniProtKB/TrEMBL
      A0A140VJU4, B3KXG0
      Related
      ENSP00000348828.4, ENST00000356448.8
      Conserved Domains (3) summary
      cd11938
      Location:793 → 847
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:643 → 781
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443 → 622
      RhoGEF; RhoGEF domain

    2. NM_001251963.2 → NP_001238892.1  rho guanine nucleotide exchange factor 26 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC018452, AK123040, DB069290
      Consensus CDS
      CCDS58858.1
      UniProtKB/TrEMBL
      B3KXG0
      Related
      ENSP00000424446.1, ENST00000496710.5
      Conserved Domains (2) summary
      cd01221
      Location:643 → 781
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443 → 622
      RhoGEF; RhoGEF domain

    3. NM_015595.4 → NP_056410.3  rho guanine nucleotide exchange factor 26 isoform 1

      See identical proteins and their annotated locations for NP_056410.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC018452, AY552599, DA248533, DB069290
      Consensus CDS
      CCDS46938.1
      UniProtKB/Swiss-Prot
      B3KVP8, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q96DR7, Q9H9D7, Q9H9R2, Q9UFW5
      UniProtKB/TrEMBL
      A0A140VJU4, B3KXG0
      Related
      ENSP00000423418.1, ENST00000465093.6
      Conserved Domains (3) summary
      cd11938
      Location:793 → 847
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:643 → 781
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443 → 622
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      154121003..154257825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512672.2 → XP_011510974.1  rho guanine nucleotide exchange factor 26 isoform X1

      See identical proteins and their annotated locations for XP_011510974.1

      UniProtKB/TrEMBL
      B3KXG0
      Conserved Domains (3) summary
      cd11938
      Location:763 → 817
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:615 → 751
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443 → 615
      RhoGEF; RhoGEF domain

    2. XM_047447954.1 → XP_047303910.1  rho guanine nucleotide exchange factor 26 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187533.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      24218..164217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328656.1 → XP_054184631.1  rho guanine nucleotide exchange factor 26 isoform X2

    2. XM_054328655.1 → XP_054184630.1  rho guanine nucleotide exchange factor 26 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      156892016..157032100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346146.1 → XP_054202121.1  rho guanine nucleotide exchange factor 26 isoform X1

    2. XM_054346147.1 → XP_054202122.1  rho guanine nucleotide exchange factor 26 isoform X2

    3. XM_054346148.1 → XP_054202123.1  rho guanine nucleotide exchange factor 26 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96DR7.4 GenPept UniProtKB/Swiss-Prot:Q96DR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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