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    erg11 putative sterol 14-demethylase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542599, updated on 11-Apr-2024

    Summary

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    Gene symbol
    erg11
    Gene description
    putative sterol 14-demethylase
    Primary source
    PomBase:SPAC13A11.02c
    Locus tag
    SPAC13A11.02c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (574652..577171, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene putative mitochondrial ribosomal protein subunit S24 Neighboring gene phospholipase D Pld1 Neighboring gene putative peptide chain release factor Neighboring gene putatiRho-type GTPase-activating protein Rga8 Neighboring gene miscRNA Neighboring gene protein Mcp7 Neighboring gene SAGA complex ubiquitin Ubp8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections. Singh A, et al. Antimicrob Agents Chemother, 2017 Nov. PMID 28893786, Free PMC Article
    2. Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast. Hirano Y, et al. J Biochem, 2023 Jun 30. PMID 36799444
    3. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Hughes AL, et al. Cell Metab, 2007 Feb. PMID 17276356
    4. Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway. Xu YJ, et al. Genetics, 2016 Nov. PMID 27585850, Free PMC Article
    5. Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis. Snaith HA, et al. J Cell Sci, 2011 Jul 1. PMID 21652630, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel erg11 mutation dramatically sensitizes cells to chronic hydroxyurea treatment. Mutation causes sterol deficiency, which may predispose the cells to the cytokinesis arrest.
      Title: Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxysterol 7-alpha-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid 7-alpha-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol 14-demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative sterol 14-demethylase
    NP_592990.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      574652..577171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018389.2 → NP_592990.1  putative sterol 14-demethylase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592990.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09736
      Conserved Domains (1) summary
      COG2124
      Location:28 → 495
      CypX; Cytochrome P450 [Secondary metabolites biosynthesis, transport and catabolism, Defense mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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