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    pst2 Clr6 histone deacetylase complex subunit Pst2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541624, updated on 11-Apr-2024

    Summary

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    Gene symbol
    pst2
    Gene description
    Clr6 histone deacetylase complex subunit Pst2
    Primary source
    PomBase:SPAC23C11.15
    Locus tag
    SPAC23C11.15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (2160354..2164078)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene zinc ion transporter Zhf1 Neighboring gene Polo kinase Plo1 Neighboring gene putative potassium ion transporter Mdm28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. Nakayama J, et al. EMBO J, 2003 Jun 2. PMID 12773392, Free PMC Article
    2. CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis. Tanaka K, et al. Dev Cell, 2009 Sep. PMID 19758558
    3. Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast. Choi ES, et al. PLoS Genet, 2012 Sep. PMID 23028377, Free PMC Article
    4. Repression of a large number of genes requires interplay between homologous recombination and HIRA. Misova I, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33511417, Free PMC Article
    5. Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection. Nicolas E, et al. Nat Struct Mol Biol, 2007 May. PMID 17450151

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3S complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Clr6 histone deacetylase complex subunit Pst2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2160354..2164078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019077.2 → NP_593646.1  Clr6 histone deacetylase complex subunit Pst2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593646.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13919
      Conserved Domains (4) summary
      COG5602
      Location:1 → 1075
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:56 → 99
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:335 → 430
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:744 → 1016
      Sin3a_C; C-terminal domain of Sin3a protein
    Nucleotide Protein
    Heading Accession and Version

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