Ppp1ca protein phosphatase 1 catalytic subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1caprovided by RGD
Official Full Name: protein phosphatase 1 catalytic subunit alphaprovided by RGD
Primary source: RGD:3375
See related: Ensembl:ENSRNOG00000018708 AllianceGenome:RGD:3375
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PP1alpha
Summary: Enables phosphoprotein phosphatase activity; protein phosphatase 1 binding activity; and ribonucleoprotein complex binding activity. Involved in protein dephosphorylation; regulation of glycogen metabolic process; and response to lead ion. Located in several cellular components, including dendritic spine; glycogen granule; and perikaryon. Part of protein phosphatase type 1 complex. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 1259.8), Spleen (RPKM 1000.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210914576..210918193)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201485117..201488734)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219439953..219443570)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP1 bound on spinophilin, a close homolog of neurabin and another major synaptic PP1 anchoring protein, does not play a role in long term depression [LTD] induction, which suggests that neurabin plays a privileged role in nanodomain targeting of PP1 in LTD induction.
Title: Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD Induction.
Data indicate that the protein phosphatase 1 (PP1) and nuclear membrane protein lamina associated polypeptide 1B (LAP1B) LAP1B:PP1 complex can be immunoprecipitated from cerebral cortex.
Title: The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.
Data show that the PP1:spinophilin holoenzyme is dynamic in solution, which allows for an increased capture radius of spinophilin and is likely important for its biological role.
Title: Flexibility in the PP1:spinophilin holoenzyme.
Data are consistent with the postsynaptic gephyrin scaffold acting as a platform for protein phosphatase 1 (PP1), which regulates gephyrin cluster size by dephosphorylation of gephyrin- or cytoskeleton-associated proteins.
Title: Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp1ca (e-PCR), detects polymorphism
- UniSTS:526866

Ppp1ca (e-PCR), detects polymorphism
- UniSTS:526867

Ppp1ca (e-PCR), detects polymorphism
- UniSTS:472882

BE099677 (e-PCR)
- UniSTS:245709

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cadherin binding involved in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lead ion	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	ISO Inferred from Sequence Orthology more info
part_of PTW/PP1 phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glycogen granule	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 1 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Names: PP-1A; Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase-1d

NP_113715.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031527.1 → NP_113715.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit

See identical proteins and their annotated locations for NP_113715.1

Status: PROVISIONAL

Source sequence(s)

D00859

UniProtKB/Swiss-Prot

P62138

UniProtKB/TrEMBL

A0A0G2JYS8, A6HYV5

Related

ENSRNOP00000025282.4, ENSRNOT00000025282.7

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain