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    Snrpc U1 small nuclear ribonucleoprotein C [ Mus musculus (house mouse) ]

    Gene ID: 20630, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snrpcprovided by MGI
    Official Full Name
    U1 small nuclear ribonucleoprotein Cprovided by MGI
    Primary source
    MGI:MGI:109489
    See related
    Ensembl:ENSMUSG00000024217 AllianceGenome:MGI:109489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U1C; U1-C; Snrp1c
    Summary
    Predicted to enable several functions, including RNA binding activity; U1 snRNP binding activity; and protein homodimerization activity. Predicted to be involved in mRNA 5'-splice site recognition and spliceosomal snRNP assembly. Predicted to be located in Cajal body. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease; mixed connective tissue disease; and systemic lupus erythematosus. Orthologous to human SNRPC (small nuclear ribonucleoprotein polypeptide C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 61.0), duodenum adult (RPKM 57.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 14.59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28059002..28070942)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27840028..27851968)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene inflammation and lipid regulator with UBA-like and NBR1-like domains Neighboring gene STARR-seq mESC enhancer starr_42174 Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene STARR-positive B cell enhancer ABC_E2475 Neighboring gene STARR-positive B cell enhancer ABC_E4198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and SAM domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and developmental expression of a small ribonuclear protein in the mouse testis. Morales CR, et al. Mol Reprod Dev, 1997 Apr. PMID 9094092
    2. RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment. Huang SC, et al. Mol Cell Biol, 2012 Jan. PMID 22083953, Free PMC Article
    3. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Sun S, et al. Nat Commun, 2015 Jan 27. PMID 25625564, Free PMC Article
    4. Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. Nelissen RL, et al. Gene, 1997 Jan 15. PMID 9031639
    5. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 5'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein C
    Names
    U1 small nuclear ribonucleoprotein 1C
    U1 snRNP C
    U1 snRNP protein C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413574.1 → NP_001400503.1  U1 small nuclear ribonucleoprotein C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126040
      UniProtKB/TrEMBL
      A0A3B2WCR6
      Related
      ENSMUSP00000156644.2, ENSMUST00000233657.2

    2. NM_001413575.1 → NP_001400504.1  U1 small nuclear ribonucleoprotein C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126040
      UniProtKB/TrEMBL
      A0A3B2W450

    3. NM_001413576.1 → NP_001400505.1  U1 small nuclear ribonucleoprotein C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126040
      UniProtKB/TrEMBL
      A0A3B2W450
      Related
      ENSMUSP00000156747.2, ENSMUST00000233752.2

    4. NM_001413577.1 → NP_001400506.1  U1 small nuclear ribonucleoprotein C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC126040

    5. NM_011432.3 → NP_035562.1  U1 small nuclear ribonucleoprotein C isoform 1

      See identical proteins and their annotated locations for NP_035562.1

      Status: VALIDATED

      Source sequence(s)
      AC126040
      Consensus CDS
      CCDS28570.1
      UniProtKB/Swiss-Prot
      Q62241
      UniProtKB/TrEMBL
      Q569X3
      Related
      ENSMUSP00000063976.8, ENSMUST00000071006.9
      Conserved Domains (1) summary
      pfam06220
      Location:1 → 38
      zf-U1; U1 zinc finger

    RNA

    1. NR_182164.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126040

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28059002..28070942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249614.1 → XP_030105474.1  U1 small nuclear ribonucleoprotein C isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62241.1 GenPept UniProtKB/Swiss-Prot:Q62241

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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